患有注意力缺陷多动障碍的青少年与成年人在症状维度上多基因效应的差异。
Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD.
作者信息
Jiang Wenhao, Rootes-Murdy Kelly, Duan Kuaikuai, Schoenmacker Gido, Hoekstra Pieter J, Hartman Catharina A, Oosterlaan Jaap, Heslenfeld Dirk, Franke Barbara, Sprooten Emma, Buitelaar Jan, Arias-Vasquez Alejandro, Liu Jingyu, Turner Jessica A
机构信息
Department of Psychology, Georgia State University, United States; Department of Psychosomatics and Psychiatry, Zhongda Hospital, Institute of Psychosomatics, Medical School, Southeast University, Nanjing, China.
Department of Psychology, Georgia State University, United States.
出版信息
Psychiatry Res Neuroimaging. 2021 May 30;311:111282. doi: 10.1016/j.pscychresns.2021.111282. Epub 2021 Mar 20.
A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.
相当一部分患有注意力缺陷多动障碍（ADHD）的人会持续到成年期。青少年与成年人ADHD的遗传和神经关联仍未得到充分描述。我们在同一个ADHD样本（来自NeuroIMAGE和IMpACT队列的462名青少年和422名成年人）中，研究了ADHD多基因风险评分（PRS）与先前确定的灰质（GM）模式、神经认知及症状表现之间的关系。发现ADHD PRS对青少年的多动和冲动症状、成年人的多动症状有显著影响，但对GM体积成分没有影响。提示青少年和成年人在个体ADHD症状上存在不同的PRS效应。
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