Department of Intensive Care, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Department of Clinical Pharmacy, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Blood Purif. 2021;50(6):971-975. doi: 10.1159/000514523. Epub 2021 Mar 29.
Extracorporeal blood purification is considered an adjunct therapy in critically ill patients with life-threatening conditions such as sepsis and septic shock. It consists of cytokine removal, removal of endotoxins, a combination of both, or the removal of pathogens themselves. The latter technique was introduced for clinical application very recently. This case study describes a case of a 69-year-old female lung transplant recipient patient with a persistent VV-ECMO-related septic deep vein thrombosis with continuous renal replacement therapy-dependent acute kidney injury initiated on the Seraph®-100 Microbind Affinity Filter in order to control the persistent bacteraemia with coagulase-negative staphylococci. Drug plasma concentrations (vancomycin, tacrolimus, and mycophenolic acid) were measured before and after the device to calculate absorber-related drug clearance.
体外血液净化被认为是一种辅助治疗方法，适用于生命垂危的危重病患者，如脓毒症和感染性休克。它包括细胞因子清除、内毒素清除、两者的组合或病原体本身的清除。后一种技术最近才被引入临床应用。本病例研究描述了一名 69 岁女性肺移植受者的病例，该患者持续存在与 VV-ECMO 相关的脓毒症深静脉血栓形成，伴有持续依赖连续性肾脏替代治疗的急性肾损伤，在 Seraph®-100 Microbind Affinity Filter 上开始使用以控制持续的凝固酶阴性葡萄球菌菌血症。在使用该设备前后测量了药物血浆浓度（万古霉素、他克莫司和霉酚酸），以计算吸附剂相关的药物清除率。
