慢性侵袭性真菌性鼻窦炎伴阴性组织病理学：诊断挑战。
Chronic Invasive Fungal Sinusitis With Negative Histopathology: A Diagnostic Challenge.
机构信息
Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
出版信息
Ear Nose Throat J. 2023 May;102(5):319-322. doi: 10.1177/0145561320973773. Epub 2021 Mar 30.
Although the diagnosis of chronic invasive fungal sinusitis relies chiefly on identification of invasive fungi on histology, the insidious nature of the disease can preclude detection of fungal organisms. Here, we present a case of chronic invasive fungal sinusitis with negative histopathologic findings and a definitive diagnosis made through fungal DNA detection. Clinicians should consider polymerase chain reaction an important complement to histology and culture in the diagnosis of chronic invasive fungal sinusitis.
虽然慢性侵袭性真菌性鼻窦炎的诊断主要依赖于组织学上侵袭性真菌的鉴定，但疾病的隐匿性可能会妨碍真菌的检测。在此，我们报告了一例慢性侵袭性真菌性鼻窦炎，其组织病理学检查结果为阴性，通过真菌 DNA 检测明确诊断。临床医生应考虑聚合酶链反应（PCR）是组织学和培养的重要补充，有助于慢性侵袭性真菌性鼻窦炎的诊断。
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