Faculty of Applied Sciences, Tunku Abdul Rahman University College (TARUC), Jalan Genting Kelang, 53300, Kuala Lumpur, Malaysia.
School of Science, Monash University Malaysia Campus, Jalan Lagoon Selatan, Bandar Sunway, 47500, Selangor, Malaysia.
Curr Med Chem. 2021;28(37):7749-7766. doi: 10.2174/0929867328666210329124415.
There have been intense research interests in sirtuins since the establishment of their regulatory roles in a myriad of pathological processes. In the last two decades, many research efforts have been dedicated to the development of sirtuin modulators. Although synthetic sirtuin modulators are the focus, natural modulators remain an integral part to be further explored in this area as they are found to possess therapeutic potential in various diseases, including cancers, neurodegenerative diseases, and metabolic disorders. Owing to the importance of this cluster of compounds, this review gives a current stand on the naturally occurring sirtuin modulators, associated molecular mechanisms, and their therapeutic benefits. Furthermore, comprehensive data mining resulted in detailed statistical data analysis pertaining to the developmental trend of sirtuin modulators from 2010-2020. Lastly, the challenges and future prospects of natural sirtuin modulators in drug discovery will also be discussed.
自发现其在众多病理过程中的调节作用以来，人们对沉默调节蛋白一直有着浓厚的研究兴趣。在过去的二十年中，许多研究工作都致力于沉默调节蛋白调节剂的开发。虽然合成沉默调节蛋白调节剂是研究的重点，但天然调节剂仍然是该领域有待进一步探索的重要组成部分，因为它们在各种疾病（包括癌症、神经退行性疾病和代谢紊乱）中具有治疗潜力。鉴于这组化合物的重要性，本综述介绍了天然沉默调节蛋白调节剂的最新研究进展，包括其相关的分子机制和治疗益处。此外，通过全面的数据挖掘，对 2010-2020 年沉默调节蛋白调节剂的发展趋势进行了详细的统计数据分析。最后，还讨论了天然沉默调节蛋白调节剂在药物发现中的挑战和未来前景。
