Department of Biochemistry, University of Allahabad, Allahabad, India.
Department of Zoology, Savitribai Phule Pune University, Pune, India.
Expert Opin Drug Discov. 2021 Aug;16(8):915-927. doi: 10.1080/17460441.2021.1915980. Epub 2021 Apr 21.
Sirtuins, NAD-dependent protein deacetylases, require NAD for enzymatic activity. Recent research has indicated that sirtuins have a key role in the regulation of gene expression, the cell cycle, apoptosis, neurodegeneration and several age-related diseases. In mammals, there are seven sirtuin isoforms (SIRT-1-7) that catalyze specific lysine substrate deacetylation.
This review explains the current information on the structure, function and importance of sirtuin modulators. It also explores the possible therapeutic applications of sirtuin modulators and related small molecules in the context of various diseases.
Sirtuin's modulators open a new area of research for targeting pathological conditions. Sirtuin modulators, through their targeted function, may provide a possible tool for the amelioration of various diseases. However, the search of activators/inhibitors for sirtuins needs further research. The structural elucidation of sirtuins will create an understanding for the development of isoform-specific selective modulators. This could be a useful tool to determine the functions of individual sirtuins as potential therapeutic agents.
依赖 NAD 的蛋白去乙酰化酶 Sirtuins 需要 NAD 才能发挥酶活性。最近的研究表明，Sirtuins 在基因表达调控、细胞周期、细胞凋亡、神经退行性变和几种与年龄相关的疾病中发挥着关键作用。在哺乳动物中，有七种 Sirtuin 同工酶（SIRT-1-7），它们催化特定赖氨酸底物的去乙酰化。
本文解释了 Sirtuin 调节剂的结构、功能和重要性的最新信息。还探讨了 Sirtuin 调节剂及其相关小分子在各种疾病背景下的潜在治疗应用。
Sirtuin 的调节剂为靶向病理状况开辟了一个新的研究领域。Sirtuin 调节剂通过其靶向功能，可能为改善各种疾病提供一种可能的工具。然而，Sirtuins 的激活剂/抑制剂的研究仍需进一步深入。Sirtuins 的结构阐明将为开发同工酶特异性选择性调节剂创造条件。这可能是确定单个 Sirtuins 作为潜在治疗剂的功能的有用工具。
