Kotecha Rupesh, Tom Martin C, Mehta Minesh P
Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Neurosurg Clin N Am. 2021 Apr;32(2):211-223. doi: 10.1016/j.nec.2020.12.007.
The standard of care treatment for glioblastoma is surgical resection followed by radiotherapy to 60 Gy with concurrent and adjuvant temozolomide with or without tumor-treating fields. Advanced imaging techniques are under evaluation to better guide radiotherapy target volume delineation and allow for dose escalation. Particle therapy, in the form of protons, carbon ions, and boron neutron capture therapy, are being assessed as strategies to improve the radiotherapeutic ratio. Stereotactic, hypofractionated, pulsed-reduced dose-rate, and particle radiotherapy are re-irradiation techniques each uniquely suited for different clinical scenarios. Novel radiotherapy approaches, such as FLASH, represent promising advancements in radiotherapy for glioblastoma.
胶质母细胞瘤的标准治疗方案是手术切除，随后进行60 Gy的放射治疗，同时和辅助使用替莫唑胺，可联合或不联合肿瘤治疗电场。先进的成像技术正在评估中，以更好地指导放射治疗靶区勾画并实现剂量递增。质子、碳离子和硼中子俘获疗法等粒子疗法正在作为提高放射治疗比的策略进行评估。立体定向、大分割、脉冲式低剂量率和粒子放射治疗是每种都独特适用于不同临床情况的再照射技术。诸如FLASH等新型放射治疗方法代表了胶质母细胞瘤放射治疗方面有前景的进展。
