Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, AL, United States.
Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, AL, United States; Department of Surgery, Division of Acute Care Surgery, University of Alabama School of Medicine, Birmingham, AL, United States; Center for Injury Science, University of Alabama School of Medicine, Birmingham, AL, United States.
Resuscitation. 2021 May;162:271-273. doi: 10.1016/j.resuscitation.2021.03.016. Epub 2021 Mar 26.
To calculate and compare the National Institutes of Health (NIH) research investment for cardiac arrest (CA) to other leading causes of disability-adjusted life years (DALY) in the United States (U.S.).
A search within NIH RePORTER for 2017 was performed using single common resuscitation terms. Grants were individually reviewed and categorized as CA research (yes/no) using predefined criteria. DALY were calculated as the sum of years of life lost (YLL) and years lived with disability (YLD) using all adult non-traumatic out-of-hospital CA (OHCA) from the CARES database for 2017. Total DALY for the study population were extrapolated to a national level. Leading causes of DALY were obtained from the Global Burden of Disease study and funding data were extracted from the NIH Categorical Spending Report for comparison. The outcome measure was U.S. dollars invested per annual DALY.
The search yielded 290 grants, of which 87 (30%) were classified as CA research. Total funding for CA research in 2017 was $37.1M. A total of 73,915 (97%) cases from CARES met study inclusion criteria for the DALY analysis. The total DALY following adult OHCA in the U.S. population were 4,335,949 (YLL 4,332,166, YLD 3784). Per annual DALY, the NIH invested $287 for diabetes, $92 for stroke, $55 for ischemic heart disease, and $9 for CA research.
The NIH investment into CA research is far less than other comparable causes of death and disability in the U.S. These results should help inform utilization of limited resources to improve public health.
计算并比较美国国立卫生研究院（NIH）在心脏骤停（CA）方面的研究投资与其他导致伤残调整生命年（DALY）的主要原因。
在 NIH RePORTER 中进行了 2017 年的搜索，使用了单一的复苏通用术语。使用预定义标准对每项拨款进行单独审查，并分类为 CA 研究（是/否）。使用 CARES 数据库中 2017 年所有成人院外非创伤性心脏骤停（OHCA）的生命损失年（YLL）和残疾生存年（YLD）计算 DALY。将研究人群的总 DALY 外推到全国水平。主要 DALY 原因来自全球疾病负担研究，从 NIH 分类支出报告中提取资金数据进行比较。结果测量指标为每年每 DALY 投资的美元数。
搜索结果产生了 290 项拨款，其中 87 项（30%）被归类为 CA 研究。2017 年 CA 研究的总资金为 3710 万美元。CARES 中共有 73915 例（97%）符合 DALY 分析的研究纳入标准。美国人群中成人 OHCA 后的总 DALY 为 4335949 人年（YLL 4332166 人年，YLD 3784 人年）。按每年每 DALY 计算，NIH 对糖尿病的投资为 287 美元，对中风的投资为 92 美元，对缺血性心脏病的投资为 55 美元，对 CA 研究的投资为 9 美元。
NIH 对 CA 研究的投资远低于美国其他可比的死亡和残疾原因。这些结果应该有助于利用有限的资源来改善公共卫生。
