LaRusso P, Jessup S A, Rogers F J, Rogers J C
Osteopathic Hospital, Trenton, Michigan.
Can J Cardiol. 1988 Apr;4(3):146-8.
Guanabenz acetate is an antihypertensive drug that is closely related to clonidine hydrochloride. Clonidine is well known to potentiate atrioventricular (AV) node conduction disturbances, but to date that effect has not been attributed to guanabenz. A case of electrocardiographic and electrophysiologic studies in a patient with both sinus and AV node conduction disturbances associated with the use of guanabenz acetate is reported. The sinus cycle length was increased by 50% after guanabenz and the sinus node recovery time was prolonged by 42%. AV block occurred proximal to the His bundle and His-ventricular prolongation of 42% also occurred. This drug should be used cautiously in patients with evidence of sinus or AV node dysfunction.
醋酸胍那苄是一种与盐酸可乐定密切相关的抗高血压药物。众所周知，可乐定可增强房室（AV）结传导紊乱，但迄今为止，这种作用尚未归因于胍那苄。本文报告了一例使用醋酸胍那苄后出现窦性和房室结传导紊乱患者的心电图和电生理研究情况。使用胍那苄后，窦性周期长度增加了50%，窦房结恢复时间延长了42%。希氏束近端出现房室传导阻滞，希氏束至心室的间期也延长了42%。对于有窦性或房室结功能障碍证据的患者，应谨慎使用此药。
