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采用基因分型技术降低小儿衣原体性结膜炎的性虐待嫌疑

Reducing suspicion of sexual abuse in paediatric chlamydial conjunctivitis using genotyping.

机构信息

Ophthalmology, Birmingham Children's Hospital, Birmingham, West Midlands, UK

Microbiology, Birmingham Children's Hospital, Birmingham, West Midlands, UK.

出版信息

BMJ Case Rep. 2021 Mar 29;14(3):e238871. doi: 10.1136/bcr-2020-238871.

Abstract

is a Gram-negative bacterium that causes urogenital tract infections, and ocular infections including trachoma, neonatal conjunctivitis and adult chlamydial inclusion conjunctivitis. A positive diagnosis in children often raises suspicions of sexual abuse. While outer membrane protein A () genotypes A-C are non-invasive and are associated with trachoma; genotypes D-K are often associated with sexually transmitted urogenital infections or sexually acquired chlamydial conjunctivitis. A 10-year-old female presented with a 7-month history of unilateral conjunctivitis with itching, watering and hyperaemia. She had recently moved from an urban centre in Afghanistan to the UK. A conjunctival swab taken from the child tested positive for Application of genotyping to conjunctival swab chlamydial DNA demonstrated that the had an genotype C. Chlamydial strains with this genotype cause trachoma and have never previously been associated with urogenital infection. This result supported cessation of child protection investigations.

摘要

是一种革兰氏阴性细菌,可引起泌尿生殖道感染和眼部感染,包括沙眼、新生儿结膜炎和成人衣原体包涵体结膜炎。儿童阳性诊断常引起性虐待的怀疑。虽然外膜蛋白 A()基因型 A-C 是非侵入性的,与沙眼有关;基因型 D-K 通常与性传播的泌尿生殖道感染或性获得性衣原体结膜炎有关。一名 10 岁女性因单侧结膜炎伴瘙痒、流泪和充血,出现 7 个月病史。她最近从阿富汗的一个城市中心搬到了英国。从孩子身上采集的结膜拭子检测出 呈阳性。应用 基因分型对结膜拭子沙眼衣原体 DNA 的检测表明,该 有一个 基因型 C。具有这种 基因型的衣原体菌株可引起沙眼,以前从未与泌尿生殖道感染有关。这一结果支持停止儿童保护调查。

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