Division of Science Education, Kangwon National University, Chuncheon, Republic of Korea.
Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Adv Exp Med Biol. 2021;1309:67-96. doi: 10.1007/978-981-33-6158-4_4.
From molecular probes, also known as fluorophores (typically emitting a longer wavelength than the absorbing wavelength), to inorganic nanoparticles, various light-emitting materials have been actively studied and developed for various applications in life science owing to their superior imaging and sensing ability. Especially after the breakthrough development of quantum dots (QDs), studies have pursued the development of the optical properties and biological applications of luminescent inorganic nanoparticles such as upconversion nanoparticles (UCNPs), metal nanoclusters, carbon dots, and so on. In this review, we first provide a brief explanation about the theoretical background and traditional concepts of molecular fluorophores. Then, currently developed luminescent nanoparticles are described as sensing and imaging platforms from general aspects to technical views.
从分子探针，也称为荧光团（通常发射比吸收波长更长的波长），到无机纳米粒子，由于它们具有优越的成像和传感能力，各种发光材料已被积极研究和开发用于生命科学中的各种应用。特别是在量子点 (QD) 的突破性发展之后，研究人员一直在追求发光无机纳米粒子（如上转换纳米粒子 (UCNP)、金属纳米簇、碳点等）的光学性质和生物应用的发展。在这篇综述中，我们首先简要解释了分子荧光团的理论背景和传统概念。然后，从一般方面到技术观点，将当前开发的发光纳米粒子描述为传感和成像平台。
