Department of Chemistry, Atma Ram Sanatan Dharma College, University of Delhi, New Delhi, India.
Department of Chemistry, University of Delhi, Delhi, India.
J Biomol Struct Dyn. 2022 Oct;40(17):8127-8141. doi: 10.1080/07391102.2021.1904004. Epub 2021 Mar 30.
The rise of normal body temperature of 98.6 °F beyond 100.4 °F in humans indicates fever due to some illness or infection. Viral infections caused by different viruses are one of the major causes of fever. One of such viruses is, Chikungunya virus (CHIKV) is known to cause Chikungunya fever (CHIKF) which is transmitted to humans through the mosquitoes, which actually become the primary source of transmission of the virus. The genomic structure of the CHIKV consists of the two open reading frames (ORFs). The first one is a 5' end ORF and it encodes the nonstructural protein (nsP1-nsP4). The second is a 3' end ORF and it encodes the structural proteins, which is consisted of capsid, envelope (E), accessory peptides, E3 and 6 K. Till date, there is no effective vaccine or medicine available for early detection of the CHIKV infection and appropriate diagnosis to cure the patients from the infection. NSP3 of CHIKV is the prime target of the researchers as it is responsible for the catalytic activity. This review has updates of literature on CHIKV; pathogenesis of CHIKV; inhibition of CHIKV using theoretical and experimental approaches.Communicated by Ramaswamy H. Sarma.
人体正常体温从 98.6°F 升高到 100.4°F 以上表明因某些疾病或感染而发烧。由不同病毒引起的病毒感染是发烧的主要原因之一。其中一种病毒是基孔肯雅病毒（CHIKV），已知会引起基孔肯雅热（CHIKF），这种病毒通过蚊子传播给人类，蚊子实际上成为病毒的主要传播源。CHIKV 的基因组结构由两个开放阅读框（ORFs）组成。第一个是 5'端 ORF，它编码非结构蛋白（nsP1-nsP4）。第二个是 3'端 ORF，它编码结构蛋白，由衣壳、包膜（E）、辅助肽、E3 和 6K 组成。迄今为止，尚无有效的疫苗或药物可用于早期检测 CHIKV 感染和进行适当诊断以治愈感染患者。CHIKV 的 NSP3 是研究人员的主要目标，因为它负责催化活性。这篇综述更新了关于 CHIKV 的文献；CHIKV 的发病机制；使用理论和实验方法抑制 CHIKV。由拉马萨米·H·萨尔马传达。
