蚊媒病毒病疫苗的研发。
Vaccine development for mosquito-borne viral diseases.
机构信息
School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
出版信息
Front Immunol. 2023 May 12;14:1161149. doi: 10.3389/fimmu.2023.1161149. eCollection 2023.
Mosquito-borne viral diseases are a group of viral illnesses that are predominantly transmitted by mosquitoes, including viruses from the Togaviridae and Flaviviridae families. In recent years, outbreaks caused by Dengue and Zika viruses from the Flaviviridae family, and Chikungunya virus from the Togaviridae family, have raised significant concerns for public health. However, there are currently no safe and effective vaccines available for these viruses, except for CYD-TDV, which has been licensed for Dengue virus. Efforts to control the transmission of COVID-19, such as home quarantine and travel restrictions, have somewhat limited the spread of mosquito-borne viral diseases. Several vaccine platforms, including inactivated vaccines, viral-vector vaccines, live attenuated vaccines, protein vaccines, and nucleic acid vaccines, are being developed to combat these viruses. This review analyzes the various vaccine platforms against Dengue, Zika, and Chikungunya viruses and provides valuable insights for responding to potential outbreaks.
蚊媒病毒病是一组主要由蚊子传播的病毒病,包括来自披膜病毒科和黄病毒科的病毒。近年来,来自黄病毒科的登革热和寨卡病毒以及披膜病毒科的基孔肯雅病毒的爆发引起了公众健康的高度关注。然而,目前除了获准用于登革热病毒的 CYD-TDV 外,这些病毒尚无安全有效的疫苗。为了控制 COVID-19 的传播,如居家隔离和旅行限制等措施,在一定程度上限制了蚊媒病毒病的传播。目前正在开发几种疫苗平台,包括灭活疫苗、病毒载体疫苗、减毒活疫苗、蛋白疫苗和核酸疫苗,以对抗这些病毒。本综述分析了针对登革热、寨卡和基孔肯雅病毒的各种疫苗平台,并为应对潜在的疫情爆发提供了有价值的见解。