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在 和 中，背腹模式之间惊人的相似性揭示了一个模型基因调控网络背后复杂的进化历史。

Striking parallels between dorsoventral patterning in and reveal a complex evolutionary history behind a model gene regulatory network.

机构信息

Institute for Zoology/Developmental Biology, Biocenter, University of Cologne, Köln, Germany.

The Natural History Museum, London, United Kingdom.

出版信息

Elife. 2021 Mar 30;10:e68287. doi: 10.7554/eLife.68287.

DOI:10.7554/eLife.68287
PMID:33783353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8051952/
Abstract

Dorsoventral pattering relies on Toll and BMP signalling in all insects studied so far, with variations in the relative contributions of both pathways. and the beetle share extensive dependence on Toll, while representatives of more distantly related lineages like the wasp and bug rely more strongly on BMP signalling. Here, we show that in the cricket , an evolutionarily distant outgroup, Toll has, like in , a direct patterning role for the ventral half of the embryo. In addition, Toll polarises BMP signalling, although this does not involve the conserved BMP inhibitor Sog/Chordin. Finally, Toll activation relies on ovarian patterning mechanisms with striking similarity to . Our data suggest two surprising hypotheses: (1) that Toll's patterning function in and is the result of convergent evolution or (2) a system arose early in insect evolution and was extensively altered in multiple independent lineages.

摘要

迄今为止，所有研究过的昆虫的背腹模式形成都依赖于 Toll 和 BMP 信号通路，这两种途径的相对贡献存在差异。甲虫和蚊子都高度依赖 Toll，而像黄蜂和蝉这样亲缘关系更远的代表则更依赖于 BMP 信号通路。在这里，我们表明在蟋蟀中，一种进化上更远的外群，Toll 像在蚊子中一样，对胚胎的腹侧半具有直接的模式形成作用。此外，Toll 使 BMP 信号极化，尽管这并不涉及保守的 BMP 抑制剂 Sog/Chordin。最后，Toll 的激活依赖于卵巢模式形成机制，与蚊子非常相似。我们的数据提出了两个令人惊讶的假设：(1)Toll 在蚊子和甲虫中的模式形成功能是趋同进化的结果，或者 (2)一个 Toll 系统在昆虫进化的早期出现，并在多个独立的谱系中被广泛改变。

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