Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Br J Surg. 2021 Aug 19;108(8):888-891. doi: 10.1093/bjs/znab088.
This prospective nationwide cohort study examined the feasibility of a watchful-waiting protocol for non-functional pancreatic neuroendocrine tumours (NF-pNET) of 2 cm or smaller. In total, 8 of 76 patients (11 per cent) with a NF-pNET no larger than 2 cm showed significant tumour progression (more than 0.5 cm/year) during 17 months of follow-up, of whom two opted for resection. No patient developed metastases. Quality of life was poorer than in the reference population. Watchful waiting seems a safe alternative to upfront surgery in patients with a NF-pNET no larger than 2 cm, although longer follow-up is necessary.
这项前瞻性全国性队列研究探讨了对 2cm 或更小的无功能性胰腺神经内分泌肿瘤 (NF-pNET) 进行静观等待方案的可行性。在总共 76 名 NF-pNET 不超过 2cm 的患者中，有 8 名（11%）在 17 个月的随访中显示出明显的肿瘤进展（每年超过 0.5cm），其中 2 名患者选择了手术切除。没有患者发生转移。生活质量较参考人群差。在 NF-pNET 不超过 2cm 的患者中，静观等待似乎是手术切除的一种安全替代方案，但需要更长时间的随访。
