Ophthalmology Department., Manisa Celal Bayar University, Manisa, Turkey.
Ophthalmology Department., Manisa Celal Bayar University, Manisa, Turkey.
Semin Ophthalmol. 2021 Oct 3;36(7):573-581. doi: 10.1080/08820538.2021.1903944. Epub 2021 Mar 30.
To analyze early quantitative changes in the choroidal neovascularization (CNV) area observed with optical coherence tomography angiography (OCTA) after single anti-vascular endothelial growth factor (anti-VEGF) injection.
Treatment-naive patients with CNV secondary to neovascular age-related macular degeneration were analyzed immediately before and ~4 weeks after anti-VEGF injection. The primary endpoints of the study included changes in CNV total and vascular area. Secondary endpoints were best-corrected visual acuity (BCVA), central macular thickness (cMT), central total macular thickness (cTMT), and subfoveal choroidal thickness (SFCT).
A total of 27 patients (69.19 ± 5.91 years, 21 men/6 women, 14 type 1 NV, 11 type 2 NV, and 2 type 3 NV) were included in the study. There was a significant increase in BCVA and decreases in cMT, cTMT, and SFCT after treatment (<0.05 for all). CNV total and vascular area changed by -11.55 ± 44.26% (95% confidence interval [CI]: -29.06 and 5.95; =0.269) and -21.06 ± 41.2% (95% CI: -36.45/-5.67; =0.786), respectively. The cases with decreased cTMT were accompanied by a decrease in CNV area only in 37% of the cases. No significant correlation was detected between cTMT and CNV total and vascular area percentage changes ( = -0.06, =0.74; = 0.02, =0.9, respectively).
Changes in CNV total and vascular area seem to have limited sensitivity as a biomarker in terms of activation, as wide variability was observed in CNV area after anti-VEGF injection.
分析光学相干断层扫描血管造影（OCTA）观察到的抗血管内皮生长因子（anti-VEGF）单药注射后脉络膜新生血管（CNV）面积的早期定量变化。
对未经治疗的新生血管性年龄相关性黄斑变性继发 CNV 患者，在抗 VEGF 注射前即刻和~4 周时进行分析。该研究的主要终点包括 CNV 总区和血管区的变化。次要终点包括最佳矫正视力（BCVA）、中央黄斑厚度（cMT）、中央总黄斑厚度（cTMT）和中心下脉络膜厚度（SFCT）。
共有 27 名患者（69.19 ± 5.91 岁，21 名男性/6 名女性，14 名 1 型 NV，11 名 2 型 NV，2 名 3 型 NV）纳入本研究。治疗后 BCVA 显著提高，cMT、cTMT 和 SFCT 降低（所有 P < 0.05）。CNV 总区和血管区分别减少了-11.55 ± 44.26%（95%置信区间 [CI]：-29.06 和 5.95；=0.269）和-21.06 ± 41.2%（95% CI：-36.45/-5.67；=0.786）。cTMT 降低的病例中，仅 37%的病例伴有 CNV 面积减少。cTMT 与 CNV 总区和血管区百分比变化之间未检测到显著相关性（= -0.06，=0.74；= -0.02，=0.9）。
CNV 总区和血管区的变化作为一种激活的生物标志物似乎敏感性有限，因为抗 VEGF 注射后 CNV 面积的变化存在很大的差异。
