母亲乙型肝炎或丙型肝炎病毒携带状态不是子女长期肿瘤发病风险的因素：一项基于人群的队列研究。

Maternal Hepatitis B or Hepatitis C Virus Carrier Status is Not a Risk Factor for Long-Term Oncologic Morbidity of the Offspring: A Population-Based Cohort Study.

机构信息

The Institute of Gastroenterology and Hepatology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

The Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

出版信息

Cancer Invest. 2021 Oct;39(9):690-695. doi: 10.1080/07357907.2021.1910704. Epub 2021 Sep 1.

DOI:10.1080/07357907.2021.1910704

PMID:33784229

Abstract

We investigated whether maternal hepatitis B virus (HBV) or hepatitis C virus (HCV) carrier status increases the risk for long-term oncologic morbidity of their offspring up to the age of 18 years. A population-based cohort study was conducted, including all singleton deliveries between the years 1991 and 2014 at a tertiary medical center. Our study included: HBV carriers ( = 588), HCV carriers ( = 183) and non-carriers ( = 241,570. No significant differences regarding oncologic morbidity were found between offspring of HBV carriers (0.2%), HCV carriers (0%) and non-carriers (0.6%; = 0.216, respectively). To conclude: maternal HBV or HCV carrier status is not a risk factor for long-term oncologic morbidity of the offspring.

摘要

我们研究了母体乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）携带状态是否会增加其子女 18 岁以下长期肿瘤发病风险。这是一项基于人群的队列研究，纳入了 1991 年至 2014 年在一家三级医疗中心的所有单胎分娩。我们的研究包括：HBV 携带者（n=588）、HCV 携带者（n=183）和非携带者（n=241570）。HBV 携带者（0.2%）、HCV 携带者（0%）和非携带者（0.6%）的子女在肿瘤发病方面无显著差异（P=0.216）。结论：母体 HBV 或 HCV 携带状态不是子女长期肿瘤发病的危险因素。