孤立性结肠腺瘤中的DNA非整倍体与结直肠癌的未来风险

DNA aneuploidy in solitary colonic adenomas and the future risk of colorectal cancer.

作者信息

Scott N A, Weiland L H, Dozois R R, Beart R W, Lieber M M

机构信息

Section of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota 55905.

出版信息

Dis Colon Rectum. 1988 Jun;31(6):423-6. doi: 10.1007/BF02552609.

DOI:10.1007/BF02552609

PMID:3378464

Abstract

Flow cytometric DNA analysis was performed on the colonic adenomas of 24 patients who had resection of an invasive colorectal carcinoma subsequent to polypectomy. The incidence of DNA aneuploidy among these adenomas was only 13 percent. Thus, simple recognition of colonic adenomas as being DNA diploid or DNA aneuploid is unlikely to be helpful for identifying patients with adenoma who are at high risk for developing a future colorectal carcinoma.

摘要

对24例在息肉切除术后接受浸润性结直肠癌切除术患者的结肠腺瘤进行了流式细胞术DNA分析。这些腺瘤中DNA非整倍体的发生率仅为13%。因此，单纯将结肠腺瘤识别为DNA二倍体或DNA非整倍体不太可能有助于识别有未来发生结直肠癌高风险的腺瘤患者。