Petrelli N J, Conte C C, Herrera L, Stulc J, O'Neill P
Roswell Park Memorial Institute, Department of Surgical Oncology, Buffalo, New York 14263.
Dis Colon Rectum. 1988 Jun;31(6):427-9. doi: 10.1007/BF02552610.
The impact on wound infection of the addition of perioperative cefamandole to a mechanical bowel preparation with oral antibiotics was studied in a prospective randomized series of patients undergoing elective colectomy for biopsy-proven carcinoma or adenomatous polyps. Seventy patients were randomized, all underwent mechanical bowel preparation and received oral neomycin and erythromycin base. Thirty-four patients also received a preoperative and four postoperative doses of cefamandole, while 36 patients were randomized to receive no parenteral antibiotics. The two groups were well stratified for age, sex, and risk factors. The Dukes stage was similar and the surgical procedures were equally distributed in the two groups. There were no wound infections in the 34 patients receiving cefamandole and only one wound infection (2.8 percent) in the 36 control patients. Therefore, the addition of perioperative intravenous cefamandole to a good mechanical bowel preparation with oral antibiotics was of no benefit in reducing wound infections following resection of colorectal malignancies in this select group of patients.
在一组经活检证实为癌或腺瘤性息肉而接受择期结肠切除术的患者中，进行了一项前瞻性随机研究，以探讨在口服抗生素进行机械性肠道准备的基础上，围手术期添加头孢孟多对伤口感染的影响。70例患者被随机分组，所有患者均接受机械性肠道准备，并口服新霉素和红霉素碱。34例患者还接受了术前和术后4剂头孢孟多，而36例患者被随机分配不接受静脉抗生素治疗。两组在年龄、性别和危险因素方面分层良好。两组的杜克分期相似，手术方式分布均匀。接受头孢孟多的34例患者中无伤口感染，36例对照患者中仅有1例伤口感染（2.8%）。因此，在这组特定患者中，在良好的口服抗生素机械性肠道准备基础上围手术期静脉添加头孢孟多，对减少结直肠恶性肿瘤切除术后的伤口感染并无益处。
