Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, China.
Complement Med Res. 2021;28(6):516-522. doi: 10.1159/000514946. Epub 2021 Mar 30.
We evaluated the efficacy of electroacupuncture combined with tropisetron in treating carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia.
A total of 264 patients aged 22-40 years were enrolled, who received carboprost tromethamine and suffered nausea and vomiting during cesarean section under lumbar anesthesia. The patients were divided randomly into the control group, electroacupuncture group, tropisetron group, and electroacupuncture + tropisetron group.
Compared to the control group, the nausea and vomiting scores decreased at T3 in both the electroacupuncture and electroacupuncture + tropisetron groups, and decreased at T4 in the electroacupuncture group, tropisetron group, and electroacupuncture + tropisetron group; the motilin, gastrin, and 5-hydroxytryptamine (5-HT) levels decreased at T5 in the other 3 groups. Compared to the electroacupuncture + tropisetron group, the nausea and vomiting scores increased at T3 in the control and tropisetron groups, and increased at T4 in the other 3 groups; the motilin, gastrin, and 5-HT levels increased at T5.
Our study suggested that electroacupuncture combined with tropisetron could effectively relieve carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia. The effect was better than its single application, and the reduced 5-HT, motilin, and gastrin levels might be involved in the underlying mechanism.
评估电针对腰麻剖宫产术中卡前列素氨丁三醇引起的恶心呕吐的疗效。
共纳入 264 例年龄 22-40 岁的患者，在接受卡前列素氨丁三醇后，在腰麻剖宫产术中出现恶心呕吐。患者随机分为对照组、电针组、托烷司琼组和电针+托烷司琼组。
与对照组相比，电针组和电针+托烷司琼组 T3 时恶心呕吐评分降低，电针组 T4 时恶心呕吐评分降低，电针组、托烷司琼组和电针+托烷司琼组 T5 时胃动素、胃泌素和 5-羟色胺（5-HT）水平降低；与电针+托烷司琼组相比，对照组和托烷司琼组 T3 时恶心呕吐评分升高，其余 3 组 T4 时恶心呕吐评分升高；电针组、托烷司琼组和电针+托烷司琼组 T5 时胃动素、胃泌素和 5-HT 水平升高。
本研究表明，电针联合托烷司琼能有效缓解腰麻剖宫产术中卡前列素氨丁三醇引起的恶心呕吐，其效果优于单一用药，降低 5-HT、胃动素和胃泌素水平可能参与其作用机制。
