Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Autophagy. 2021 May;17(5):1063-1064. doi: 10.1080/15548627.2021.1905974. Epub 2021 Mar 31.
VCP, a conserved ATPase, is involved in several cellular processes, and mutations in this protein are associated with various diseases. VCP also plays a role in autophagosome maturation. However, because a deficiency in autophagosome maturation presents a readily observable phenotype, other roles of VCP in autophagy regulation, in particular in the initial steps of autophagosome formation, may have been overlooked. In a recently published paper, using small-molecule inhibitors, Hill . showed that VCP regulates autophagy initiation through both stabilization of BECN1 and enhancement of phosphati-dylinositol 3-kinase (PtdIns3K) complex assembly.
VCP（一种保守的 ATP 酶）参与了多种细胞过程，该蛋白的突变与多种疾病有关。VCP 还在自噬体成熟过程中发挥作用。然而，由于自噬体成熟的缺陷会表现出易于观察的表型，因此 VCP 在自噬调节中的其他作用，特别是在自噬体形成的初始步骤中，可能被忽视了。在最近发表的一篇论文中，Hill 使用小分子抑制剂表明，VCP 通过稳定 BECN1 和增强磷脂酰肌醇 3-激酶（PtdIns3K）复合物组装来调节自噬体的形成。
