Meyer Hemmo, Weihl Conrad C
Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany
Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
J Cell Sci. 2014 Sep 15;127(Pt 18):3877-83. doi: 10.1242/jcs.093831. Epub 2014 Aug 21.
The ATPase valosin-containing protein (VCP)/p97 has emerged as a central and important element of the ubiquitin system. Together with a network of cofactors, it regulates an ever-expanding range of processes that stretch into almost every aspect of cellular physiology. Its main role in proteostasis and key functions in signaling pathways are of relevance to degenerative diseases and genomic stability. In this Cell Science at a Glance and the accompanying poster, we give a brief overview of this complex system. In addition, we discuss the pathogenic basis for VCP/p97-associated diseases and then highlight in more detail new exciting links to the translational stress response and RNA biology that further underscore the significance of the VCP/p97 system.
三磷酸腺苷酶含缬酪肽蛋白（VCP）/p97已成为泛素系统的核心且重要的组成部分。它与一系列辅助因子网络一起，调节着不断扩大的各种过程，这些过程几乎延伸到细胞生理学的各个方面。它在蛋白质稳态中的主要作用以及在信号通路中的关键功能与退行性疾病和基因组稳定性相关。在本期“细胞科学一览”及随附的海报中，我们简要概述了这个复杂的系统。此外，我们讨论了VCP/p97相关疾病的致病基础，然后更详细地强调了与翻译应激反应和RNA生物学的新的令人兴奋的联系，这些联系进一步突出了VCP/p97系统的重要性。
