Laurence A S
Department of Anaesthetics, Royal Preston Hospital, United Kingdom.
Eur J Anaesthesiol. 1988 Jan;5(1):31-8.
Serum myoglobin was measured in 40 children (mean age 5 yrs) following suxamethonium administration during anaesthesia for tonsillectomy. Half were given an i.v. induction while half were given an inhalation induction. Pre-treatment with alcuronium 0.04 mg kg-1 prior to suxamethonium administration was given to half the patients in each group. Mean pre-induction serum myoglobin was 11.8 micrograms litre-1. Following i.v. induction there was a marked rise of serum myoglobin in the control subgroup to a mean of 113 micrograms litre-1 20 min after suxamethonium administration. There was no such rise in the pre-treatment subgroup. In the inhalation control subgroup, there was a much larger mean rise to 537 micrograms litre-1 (significantly greater than in the control IV group), one patient reaching 2800 micrograms litre-1 20 min after suxamethonium administration. Pre-treatment greatly reduced but did not totally prevent the rise following inhalation induction.
在40名儿童（平均年龄5岁）扁桃体切除术中麻醉期间给予琥珀胆碱后测量血清肌红蛋白。一半儿童接受静脉诱导，另一半接受吸入诱导。每组中有一半患者在给予琥珀胆碱之前先给予阿库氯铵0.04mg/kg进行预处理。诱导前血清肌红蛋白的平均值为11.8微克/升。静脉诱导后，对照组亚组血清肌红蛋白在给予琥珀胆碱20分钟后显著升高至平均113微克/升。预处理亚组中没有出现这种升高。在吸入对照组亚组中，平均升高幅度大得多，达到537微克/升（显著高于静脉注射对照组），一名患者在给予琥珀胆碱20分钟后达到2800微克/升。预处理大大降低了吸入诱导后的升高，但并未完全阻止这种升高。
