Newman M E, Lerer B
Department of Research, Jerusalem Mental Health Center, Israel.
Eur J Pharmacol. 1988 Mar 29;148(2):257-60. doi: 10.1016/0014-2999(88)90571-7.
The degree of inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT and by carbachol in hippocampal membranes was significantly reduced after administration of either chronic ECS (10 days) or desimipramine (10 mg/kg i.p. for 3 weeks). A single ECS had no effect on the 5-HT response and slightly augmented the carbachol response. These results parallel previous observations on the effects of ECS and antidepressants on behavioral responses to 5-HT1a agonists and on muscarinic receptor number, and indicate the possible involvement of these receptors in the mechanism of action of antidepressant drugs.
在给予慢性电休克（10天）或地昔帕明（10mg/kg腹腔注射，持续3周）后，5-羟色胺（5-HT）和卡巴胆碱对海马膜中福斯高林刺激的腺苷酸环化酶活性的抑制程度显著降低。单次电休克对5-HT反应没有影响，却略微增强了卡巴胆碱反应。这些结果与先前关于电休克和抗抑郁药对5-HT1a激动剂行为反应及毒蕈碱受体数量影响的观察结果相似，表明这些受体可能参与了抗抑郁药物的作用机制。
