二盐酸布雷维卡林——一种新型原创抗心律失常药物
[Brevikarin dihydrochloride--a new original anti-arrhythmia agent].
作者信息
Denisenko P P, Vinogradova T V, Semenov A A
出版信息
Farmakol Toksikol. 1988 Mar-Apr;51(2):50-3.
PMID:3378605
Abstract
On six models of arrhythmias of atrial and ventricular types (induced by administration of aconitine, chlorcalcium, chlorbarium, strophanthin, chloroform-adrenaline and by coronary occlusion) it was shown that in rats, cats and rabbits the antiarrhythmic, preventive and relieving activity of brevicarine dichlorhydrate exceeded that of quinidine, novocainamide and lidocaine in power by 3-5 times and in duration by 3-18 times.
摘要
在六种心房和心室型心律失常模型（由乌头碱、氯化钙、氯化钡、毒毛花苷、氯仿 - 肾上腺素诱导以及冠状动脉闭塞诱导）上的实验表明，在大鼠、猫和兔子身上，二盐酸短葶山麦冬碱的抗心律失常、预防和缓解活性在效力上比奎尼丁、新斯的明和利多卡因强3 - 5倍，在持续时间上比它们长3 - 18倍。
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