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[锂制剂与抗心律失常药物在毒毛花苷、氯化钙和氯化钡所致实验性心律失常中活性的比较特征]

[Comparative characteristics of the activity of lithium preparations and anti-arrhythmia agents in strophanthin, calcium chloride and barium chloride arrhythmias in an experiment].

作者信息

Galenko-Iaroshevskiĭ P A, Tikhonov A V

出版信息

Farmakol Toksikol. 1985 Mar-Apr;48(2):64-8.

PMID:3996574
Abstract

During disorders of cardiac rhythm induced by strophanthine K in anesthesized cats, by calcium chloride in mice and anesthesized rats, and by barium chloride in rabbits, lithium hydroxybutyrate (0.55-3.2 mg/kg according to cation) compares very favourably with lithium chloride, novocainamide, lidocaine, trimecaine, etmozine, quinidine and verapamil as regards antiarrhythmic activity and the range of therapeutic action.

摘要

在毒毛花苷K诱发麻醉猫心律失常、氯化钙诱发小鼠和麻醉大鼠心律失常以及氯化钡诱发家兔心律失常的实验中,就抗心律失常活性和治疗作用范围而言,γ-羟基丁酸锂(按阳离子计为0.55 - 3.2毫克/千克)与氯化锂、新斯的明、利多卡因、三甲卡因、乙吗噻嗪、奎尼丁和维拉帕米相比,效果非常好。

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