Kiselev V I, Shakhmatov I I
Farmakol Toksikol. 1988 Mar-Apr;51(2):63-6.
A direct effect of the preparation of pancreatic kallikrein on plasma hemostasis state was shown in experiments in vitro. Incubation of plasma with kallikrein led to an insignificant activation of contact factors of coagulation and suppression of the final stages of the clot formation at the level of the active thrombin formation and the fibrin-monomer polymerization. The growth of the anticoagulant and fibrinolytic activity was found. The possibility of studying the preparation as a thrombolytic agent in thrombotic situations is discussed.
体外实验表明了胰腺激肽释放酶制剂对血浆止血状态的直接影响。血浆与激肽释放酶孵育导致凝血接触因子的激活不显著，并在活性凝血酶形成和纤维蛋白单体聚合水平上抑制凝血的最终阶段。发现抗凝和纤溶活性增强。讨论了在血栓形成情况下将该制剂作为溶栓剂进行研究的可能性。
