Scholl Ashley Rose, Nasr Layla, Serrano Cesar A, Castellani Rudy J
Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University, Morgantown, USA.
Department of Radiology, West Virginia University, Morgantown, USA.
Cureus. 2021 Feb 24;13(2):e13537. doi: 10.7759/cureus.13537.
Chordoid gliomas arise near the third ventricle and commonly present around 40 years of age. These rare tumors are non-invasive and often present with headaches and visual disturbances. Contrast enhancement on MRI is typical for these tumors and immunohistochemical (IHC) staining is positive for glial fibrillary acidic protein (GFAP). Surgical resection is the treatment of choice. We present this case of chordoid glioma because of its unique characteristics. The tumor lacked contrast enhancement on MRI and demonstrated juxtanuclear dot-like immunoreactivity for synaptophysin which is a feature not previously reported in the literature. It is important for pathologists and radiologists to be on the lookout for atypical presentations of these rare tumors.
脊索样胶质瘤起源于第三脑室附近，通常在40岁左右出现。这些罕见的肿瘤是非侵袭性的，常表现为头痛和视觉障碍。MRI上的对比增强是这些肿瘤的典型表现，免疫组织化学（IHC）染色显示胶质纤维酸性蛋白（GFAP）呈阳性。手术切除是首选的治疗方法。我们展示这个脊索样胶质瘤病例是因为其独特的特征。该肿瘤在MRI上缺乏对比增强，并且对突触素表现出核旁点状免疫反应性，这是文献中以前未报道过的特征。病理学家和放射科医生留意这些罕见肿瘤的非典型表现很重要。
