Calanchini Matilde, Cudlip Simon, Hofer Monika, Byrne James, Fabbri Andrea, Grossman Ashley
Department of Endocrinology, OCDEM, Churchill Hospital Oxford, Oxford, UK.
Endocrinology Unit, Department of Systems Medicine, S. Eugenio and CTO A. Alesini Hospitals, University Tor Vergata, Rome, Italy.
Pituitary. 2016 Aug;19(4):356-61. doi: 10.1007/s11102-016-0711-8.
Chordoid glioma of the third ventricle is a rare and recently described tumor characterized by a unique histomorphology and exclusive association with the suprasellar/third ventricular compartment. Its clinical, radiological and histological features may vary. Despite the fact that chordoid glioma is a low-grade tumor, its prognosis has been relatively poor because of its insidious presentation and the difficulty in obtaining complete surgical resection.
Here, we report on a new case of chordoid glioma occurring in a 48-year-old woman, presented with hyponatremia, and on the initial work-up with a diagnosis of hyponatremia due at least in part to SIADH. We review the current literature on this rare pathology, discuss the radiological and histopathologic findings, and discuss the optimal management of chordoid glioma in general.
Based on this new case and the previous literature reports, we suggest that chordoid glioma should be included in the differential diagnosis of uncommon masses of the third ventricle, especially in middle-aged women, and we emphasize current management guidelines.
第三脑室脊索样胶质瘤是一种罕见的、近期才被描述的肿瘤，其特征为独特的组织形态学以及仅与鞍上/第三脑室区域相关。其临床、放射学及组织学特征可能有所不同。尽管脊索样胶质瘤是一种低级别肿瘤，但因其隐匿的表现以及难以实现完全手术切除，其预后相对较差。
在此，我们报告一例发生于一名48岁女性的新的脊索样胶质瘤病例，该患者表现为低钠血症，初步检查诊断为低钠血症至少部分归因于抗利尿激素分泌异常综合征（SIADH）。我们回顾了关于这种罕见病理的当前文献，讨论了放射学和组织病理学发现，并总体讨论了脊索样胶质瘤的最佳治疗方法。
基于这一新病例及先前的文献报道，我们建议脊索样胶质瘤应纳入第三脑室罕见肿块的鉴别诊断中，尤其是在中年女性中，并强调当前的治疗指南。
