Wee Liang En, Wong Crystal Shie Lyeen, Tan Ai Ling, Oh Helen May-Lin
SingHealth Infectious Diseases Residency, Outram Road, 169608, Singapore.
Department of Infectious Diseases, Changi General Hospital, Simei St 3, 529889, Singapore.
Med Mycol Case Rep. 2021 Mar 5;32:47-49. doi: 10.1016/j.mmcr.2021.03.003. eCollection 2021 Jun.
Candida infections of the central nervous system (CNS) are rare. We report a case of Candida glabrata meningitis successfully treated with combination antifungal therapy followed by step-down therapy with fluconazole. New-onset hypercalcaemia, an uncommon side effect of the prolonged fluconazole treatment, prompted early treatment cessation. A negative cerebrospinal fluid (CSF) β-d-glucan supported the decision of treatment cessation despite incomplete resolution of CSF biochemical parameters. No disease relapse was encountered after 2 years post-treatment.
中枢神经系统（CNS）念珠菌感染较为罕见。我们报告一例光滑念珠菌脑膜炎病例，该病例通过联合抗真菌治疗成功治愈，随后采用氟康唑降阶梯治疗。新发高钙血症是氟康唑长期治疗罕见的副作用，促使提前停药。尽管脑脊液生化指标未完全恢复正常，但脑脊液β - d - 葡聚糖检测结果为阴性，支持了停药的决定。治疗后2年未出现疾病复发。
