高血清肿瘤坏死因子受体 1 水平与老年人低内在能力风险相关。

High Serum Tumor Necrosis Factor Receptor 1 Levels Are Related to Risk of Low Intrinsic Capacity in Elderly Adults.

机构信息

Dr. Lina Ma, Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, 45 Changchun Street, Xicheng District, Beijing 100053, China. E-mail:

出版信息

J Nutr Health Aging. 2021;25(4):416-418. doi: 10.1007/s12603-020-1533-y.

DOI:10.1007/s12603-020-1533-y

PMID:33786556

Abstract

OBJECTIVES

To explore the association between inflammatory cytokines and intrinsic capacity in older adults.

METHOD

Data were retrieved from the Cardiovascular Health, Cognition and Aging Study. A total of 130 participants aged 60-99 years (mean age 73.11±9.02 years) were recruited. Intrinsic capacity was assessed by the five domains recommended by the World Health Organization: locomotion, cognition, vitality, sensory and psychological domains. Circulating interleukin-6, tumor necrosis factor receptor 1 (TNFR1), insulin-like growth factor-1, and vaspin levels were measured. Logistic regression was conducted for factors associated with intrinsic capacity decline.

RESULTS

Intrinsic capacity decline was associated with older age, kidney diseases, olfactory disturbances and lower grip strength. Logistic regression showed that circulating TNFR1 was independently associated with intrinsic capacity decline after adjustments for age, sex, education, chronic diseases, grip strength, and physical activity.

CONCLUSION

Elevated circulating TNFR1 levels are independently associated with declined intrinsic capacity, suggesting that chronic inflammation may underlie intrinsic capacity decline.

摘要

目的

探讨老年人群中炎症细胞因子与内在能力的关系。

方法

数据来自心血管健康、认知和衰老研究。共招募了 130 名年龄在 60-99 岁之间的参与者（平均年龄 73.11±9.02 岁）。内在能力通过世界卫生组织推荐的五个领域进行评估：运动能力、认知能力、活力、感官和心理领域。测量了循环白细胞介素-6、肿瘤坏死因子受体 1（TNFR1）、胰岛素样生长因子-1 和 vaspin 水平。进行了逻辑回归分析，以确定与内在能力下降相关的因素。