Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France.
Maintain Aging Research Team, CERPOP, Inserm, Université Paul Sabatier, Toulouse, France.
J Cachexia Sarcopenia Muscle. 2023 Apr;14(2):930-939. doi: 10.1002/jcsm.13163. Epub 2023 Jan 20.
How inflammation relates to intrinsic capacity (IC), the composite of physical and mental capacities, remains undefined. Our study aimed to investigate the cross-sectional and longitudinal associations between plasma inflammation-related biomarkers and IC in older adults.
This secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) included 1238 community-dwelling older individuals with IC assessments from 12 to 60 months. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor receptor-1 (TNFR-1), monocyte chemoattractant protein-1 (MCP-1) and growth differentiation factor-15 (GDF-15) were measured at 12 months. IC was operationalized as a score ranging from 0 to 100, derived from four domains: cognition, Mini-Mental State Examination; locomotion, Short Physical Performance Battery; psychological, Geriatric Depression Scale; and vitality, handgrip strength. A five-domain IC score (plus sensory) was investigated in a subsample (n = 535) with a 1-year follow-up as an exploratory outcome.
The mean age of the 1238 participants was 76.2 years (SD = 4.3); 63.7% were female. Their initial four-domain IC scores averaged 78.9 points (SD = 9.3), with a yearly decline of 1.17 points (95% CI = -1.30 to -1.05; P < 0.001). We observed significant associations of lower baseline IC with higher CRP, IL-6, TNFR-1 and GDF-15, after controlling age, sex, MAPT group allocation and educational level [CRP: adjusted β (95% CI) = -1.56 (-2.64 to -0.48); P = 0.005; IL-6: adjusted β = -3.16 (-4.82 to -1.50); P < 0.001; TNFR-1: adjusted β = -6.86 (-10.25 to -3.47); P < 0.001; GDF-15: adjusted β = -7.07 (-10.02 to -4.12); P < 0.001]. Higher TNFR-1, MCP-1 and GDF-15 were associated with faster decline in four-domain IC over 4 years [TNFR-1: adjusted β (95% CI) = -1.28 (-2.29 to -0.27); P = 0.013; MCP-1: adjusted β = -1.33 (-2.24 to -0.42); P = 0.004; GDF-15: adjusted β = -1.42 (-2.26 to -0.58); P = 0.001]. None of the biomarkers was significantly associated with the five-domain IC decline.
Inflammation was associated with lower IC in older adults. Among all plasma biomarkers, TNFR-1 and GDF-15 were consistently associated with IC at the cross-sectional and longitudinal levels.
炎症与内在能力（IC）之间的关系仍未得到明确界定，IC 是身体和心理能力的综合表现。我们的研究旨在调查老年人群中血浆炎症相关生物标志物与 IC 之间的横断面和纵向关联。
本研究是对多领域阿尔茨海默病预防试验（MAPT）的二次分析，共纳入了 1238 名具有 IC 评估的社区居住的老年个体，IC 评估时间为 12 至 60 个月。在 12 个月时测量了血浆 C 反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子受体-1（TNFR-1）、单核细胞趋化蛋白-1（MCP-1）和生长分化因子-15（GDF-15）。IC 被定义为一个 0 到 100 分的评分，由四个领域组成：认知、简易精神状态检查；运动，短体功测试；心理，老年抑郁量表；和活力，握力。在一个随访时间为 1 年的亚样本（n=535）中，研究了一个五域 IC 评分（加感官）作为探索性结果。
1238 名参与者的平均年龄为 76.2 岁（SD=4.3），63.7%为女性。他们最初的四个领域 IC 平均得分为 78.9 分（SD=9.3），每年下降 1.17 分（95%CI=-1.30 至-1.05；P<0.001）。我们观察到较低的基线 IC 与较高的 CRP、IL-6、TNFR-1 和 GDF-15 显著相关，在控制年龄、性别、MAPT 组分配和教育水平后[CRP：调整后的β（95%CI）=-1.56（-2.64 至-0.48）；P=0.005；IL-6：调整后的β=-3.16（-4.82 至-1.50）；P<0.001；TNFR-1：调整后的β=-6.86（-10.25 至-3.47）；P<0.001；GDF-15：调整后的β=-7.07（-10.02 至-4.12）；P<0.001]。较高的 TNFR-1、MCP-1 和 GDF-15 与四年内四个领域的 IC 快速下降相关[TNFR-1：调整后的β（95%CI）=-1.28（-2.29 至-0.27）；P=0.013；MCP-1：调整后的β=-1.33（-2.24 至-0.42）；P=0.004；GDF-15：调整后的β=-1.42（-2.26 至-0.58）；P=0.001]。没有一种生物标志物与五域 IC 下降显著相关。
炎症与老年人的 IC 较低有关。在所有的血浆生物标志物中，TNFR-1 和 GDF-15 在横断面和纵向水平上均与 IC 一致相关。
