Pancreatic cancer immune evasion mechanisms: the immunosuppressive role of P2RX1-negative neutrophils.
作者信息
Audrito Valentina
机构信息
Molecular Biotechnology Center & Department Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.
出版信息
Purinergic Signal. 2021 Jun;17(2):173-174. doi: 10.1007/s11302-021-09782-x. Epub 2021 Mar 30.
Abstract
摘要
相似文献
1
Pancreatic cancer immune evasion mechanisms: the immunosuppressive role of P2RX1-negative neutrophils.胰腺癌免疫逃逸机制：P2RX1 阴性中性粒细胞的免疫抑制作用
Purinergic Signal. 2021 Jun;17(2):173-174. doi: 10.1007/s11302-021-09782-x. Epub 2021 Mar 30.
2
Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis.鉴定胰腺癌肝转移中存在一小部分免疫抑制性 P2RX1 阴性中性粒细胞。
Nat Commun. 2021 Jan 8;12(1):174. doi: 10.1038/s41467-020-20447-y.
3
Immune Cell Modulation of the Extracellular Matrix Contributes to the Pathogenesis of Pancreatic Cancer.免疫细胞对细胞外基质的调节作用有助于胰腺癌的发病机制。
Biomolecules. 2021 Jun 17;11(6):901. doi: 10.3390/biom11060901.
4
Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer.BH4 代谢失调促进胰腺癌中的免疫抑制。
Cell Metab. 2024 May 7;36(5):886-888. doi: 10.1016/j.cmet.2024.04.009.
5
Targeting the microenvironment of pancreatic cancer: overcoming treatment barriers and improving local immune responses.靶向胰腺癌微环境：克服治疗障碍并改善局部免疫反应。
Clin Transl Oncol. 2016 Jul;18(7):653-9. doi: 10.1007/s12094-015-1459-8. Epub 2015 Dec 11.
6
Targeting the tumor microenvironment for pancreatic ductal adenocarcinoma therapy.靶向肿瘤微环境用于胰腺癌治疗
Chin Clin Oncol. 2019 Apr;8(2):18. doi: 10.21037/cco.2019.03.02.
7
Thrombin Signaling Promotes Pancreatic Adenocarcinoma through PAR-1-Dependent Immune Evasion.凝血酶信号通过 PAR-1 依赖性免疫逃避促进胰腺导管腺癌。
Cancer Res. 2019 Jul 1;79(13):3417-3430. doi: 10.1158/0008-5472.CAN-18-3206. Epub 2019 May 2.
8
The immune network in pancreatic cancer development and progression.胰腺癌发生发展中的免疫网络
Oncogene. 2014 Jun 5;33(23):2956-67. doi: 10.1038/onc.2013.257. Epub 2013 Jul 15.
9
An Immunological Glance on Pancreatic Ductal Adenocarcinoma.胰腺导管腺癌的免疫学观察。
Int J Mol Sci. 2020 May 8;21(9):3345. doi: 10.3390/ijms21093345.
10
Pancreatic Stellate Cells Promote Tumor Progression by Promoting an Immunosuppressive Microenvironment in Murine Models of Pancreatic Cancer.胰腺星状细胞通过促进胰腺癌小鼠模型中的免疫抑制微环境促进肿瘤进展。
Pancreas. 2020 Jan;49(1):120-127. doi: 10.1097/MPA.0000000000001464.
引用本文的文献
1
P2RX1 in neutrophils mediates JAK/STAT signaling pathway to regulate malignant phenotype of gastric Cancer cells.中性粒细胞中的P2RX1介导JAK/STAT信号通路，以调节胃癌细胞的恶性表型。
Mol Genet Genomics. 2025 Feb 22;300(1):23. doi: 10.1007/s00438-025-02227-9.
2
Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment.胰腺癌中的免疫抑制、免疫逃逸和免疫治疗：聚焦于肿瘤微环境
Cell Oncol (Dordr). 2023 Feb;46(1):17-48. doi: 10.1007/s13402-022-00741-1. Epub 2022 Nov 11.
3
NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma.非编码RNA介导的P2RX1表达与乳腺浸润性癌患者的临床结局和免疫浸润相关。
Aging (Albany NY). 2022 May 18;14(10):4471-4485. doi: 10.18632/aging.204087.
本文引用的文献
1
Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis.鉴定胰腺癌肝转移中存在一小部分免疫抑制性 P2RX1 阴性中性粒细胞。
Nat Commun. 2021 Jan 8;12(1):174. doi: 10.1038/s41467-020-20447-y.
2
From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer.从最先进的治疗方法到晚期胰腺癌的新型疗法。
Nat Rev Clin Oncol. 2020 Feb;17(2):108-123. doi: 10.1038/s41571-019-0281-6. Epub 2019 Nov 8.
3
Extracellular ATP and P2 purinergic signalling in the tumour microenvironment.细胞外 ATP 与肿瘤微环境中的 P2 嘌呤能信号转导。
Nat Rev Cancer. 2018 Oct;18(10):601-618. doi: 10.1038/s41568-018-0037-0.
4
Purinergic Regulation of Neutrophil Function.嘌呤能调节中性粒细胞功能。
Front Immunol. 2018 Mar 1;9:399. doi: 10.3389/fimmu.2018.00399. eCollection 2018.
5
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.增强子重编程促进胰腺癌转移。
Cell. 2017 Aug 24;170(5):875-888.e20. doi: 10.1016/j.cell.2017.07.007. Epub 2017 Jul 27.
6
An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer.一种免疫抑制性树突状细胞亚群在胰腺癌细胞的转移部位聚集并促进转移。
Cancer Res. 2017 Aug 1;77(15):4158-4170. doi: 10.1158/0008-5472.CAN-16-2212. Epub 2017 Jun 13.
7
Purinergic regulation of the immune system.嘌呤能免疫系统调节。
Nat Rev Immunol. 2016 Mar;16(3):177-92. doi: 10.1038/nri.2016.4.
8
Neutrophils in the Tumor Microenvironment.肿瘤微环境中的中性粒细胞
Trends Immunol. 2016 Jan;37(1):41-52. doi: 10.1016/j.it.2015.11.008. Epub 2015 Dec 14.
9
Microenvironmental regulation of tumor progression and metastasis.肿瘤演进和转移的微环境调控。
Nat Med. 2013 Nov;19(11):1423-37. doi: 10.1038/nm.3394.
10
The immune contexture in human tumours: impact on clinical outcome.人类肿瘤中的免疫结构：对临床结果的影响。
Nat Rev Cancer. 2012 Mar 15;12(4):298-306. doi: 10.1038/nrc3245.
Zotero 插件