BH4 代谢失调促进胰腺癌中的免疫抑制。
Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer.
机构信息
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
出版信息
Cell Metab. 2024 May 7;36(5):886-888. doi: 10.1016/j.cmet.2024.04.009.
PMID:38718754
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive, malignant, and lethal cancers, displaying strong resistance to immunotherapy. In this issue of Cell Metabolism, a study by Liu et al. identifies tetrahydrobiopterin metabolic dysregulation as a key driver for the immunosuppressive PDAC environment in mouse and human.
摘要
胰腺导管腺癌（PDAC）是最具侵袭性、恶性和致命的癌症之一，对免疫疗法具有很强的抵抗力。在本期《细胞代谢》中，Liu 等人的研究表明，四氢生物蝶呤代谢失调是导致小鼠和人类 PDAC 免疫抑制微环境的关键驱动因素。
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