Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China.
Fuchunjiang Road Community Health Service Center, West Coast New District, Qingdao, China.
Asia Pac J Clin Nutr. 2021;30(1):87-98. doi: 10.6133/apjcn.202103_30(1).0011.
PUFAs play critical roles in the development of nonalcoholic fatty liver disease (NAFLD). This study examined the associations between dietary n-3 and n-6 PUFA intake and NAFLD risk in a US population.
Data from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 was used in this cross-sectional study. Data on dietary n-3 and n-6 PUFAs were extracted through two 24-h dietary recall interviews, and the dietary n-3 and n-6 PUFA intakes were adjusted by weight. NAFLD was defined based on the US fatty liver index (FLI) value ≥30. Multivariable logistic regression models and restricted cubic spline models were applied to investigate the associations between dietary n-3 and n-6 PUFA intakes and NAFLD risk.
Dietary n-3 and n-6 PUFA intakes were inversely associated with NAFLD risk. The multivariable-adjusted OR (95% CI) of NAFLD for the highest versus lowest quartile of dietary n-3 and n-6 PUFA intakes was 0.24 (0.17-0.35) and 0.18 (0.13-0.26), respectively. In stratified analyses by sex and age, the negative associations between dietary n-3 and n-6 PUFA intakes and NAFLD risk were significant in men, women, and individuals younger and older than 45 years. Dose-response analyses indicated that NAFLD risk was associated with dietary n-3 and n-6 PUFA intakes in a nonlinear manner.
Dietary n-3 and n-6 PUFA intakes were inversely associated with NAFLD risk in US adults.
多不饱和脂肪酸（PUFAs）在非酒精性脂肪性肝病（NAFLD）的发展中起着关键作用。本研究在美国人群中研究了饮食中 n-3 和 n-6 PUFAs 摄入与 NAFLD 风险之间的关系。
本横断面研究使用了 2007-2014 年全国健康和营养调查（NHANES）的数据。通过两次 24 小时膳食回忆访谈提取饮食 n-3 和 n-6 PUFAs 数据，并根据体重调整饮食 n-3 和 n-6 PUFAs 摄入量。NAFLD 定义为美国脂肪肝指数（FLI）值≥30。应用多变量逻辑回归模型和限制立方样条模型来研究饮食 n-3 和 n-6 PUFAs 摄入量与 NAFLD 风险之间的关系。
饮食 n-3 和 n-6 PUFAs 摄入量与 NAFLD 风险呈负相关。饮食 n-3 和 n-6 PUFAs 摄入量最高与最低四分位数相比，NAFLD 的多变量校正比值比（95%CI）分别为 0.24（0.17-0.35）和 0.18（0.13-0.26）。在按性别和年龄分层分析中，饮食 n-3 和 n-6 PUFAs 摄入量与 NAFLD 风险之间的负相关关系在男性、女性以及年龄小于或大于 45 岁的个体中均有统计学意义。剂量反应分析表明，NAFLD 风险与饮食 n-3 和 n-6 PUFAs 摄入量呈非线性关系。
美国成年人饮食 n-3 和 n-6 PUFAs 摄入量与 NAFLD 风险呈负相关。
