不同来源的膳食铁摄入与成年人非酒精性脂肪肝的关系。

Associations between dietary iron intake from different sources and non-alcoholic fatty liver disease in adults.

机构信息

Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China.

Department of Laboratory, Affiliated Women and Children's Hospital of Qingdao University, Qingdao, China.

出版信息

Asia Pac J Clin Nutr. 2024 Sep;33(3):413-423. doi: 10.6133/apjcn.202409_33(3).0012.

DOI:10.6133/apjcn.202409_33(3).0012

PMID:38965729

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11389813/

Abstract

BACKGROUND AND OBJECTIVES

Non-alcoholic fatty liver disease (NAFLD) has become a worldwide public health problem. Current evidence on the association between dietary iron intake and the risk of NAFLD is limited. The present study aimed to investigate the associations of animal-derived dietary iron (ADDI) intake, plant-derived dietary iron (PDDI) intake, and the ratio of PDDI:ADDI with NAFLD risk among U.S. adult population.

METHODS AND STUDY DESIGN

This was a repeated cross-sectional study. Data were collected from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. NAFLD was defined as a United States Fatty Lives Index ≥30, and dietary iron intake was assessed through two 24-h dietary recall in-terviews. Logistic regression and restricted cubic spline models were applied to examine the associations between dietary iron intake from different sources and NAFLD risk.

RESULTS

A total of 9478 participants aged ≥20 years were enrolled in the present study. After adjustment for multiple confounding factors, relative to the lowest quartile, the odds ratio (OR) and 95% confidence interval (CI) of NAFLD for the highest quartile was 1.01(95% CI, 0.82-1.24) for ADDI intake, 0.82 (95% CI, 0.64-0.99) for PDDI intake, and 1.00 (95% CI, 0.81-1.24) for the PDDI: ADDI intake ratio. In stratified analysis by sex and age, the significantly negative associations of PDDI intake with NAFLD was observed in women and participants older than 45 years. Dose-response analyses indicated that NAFLD was negatively associated with PDDI intake in a non-linear manner.

CONCLUSIONS

PDDI intake was negatively associated with NAFLD in U.S. adults.

摘要

背景和目的

非酒精性脂肪性肝病（NAFLD）已成为全球性的公共卫生问题。目前关于膳食铁摄入量与 NAFLD 风险之间关联的证据有限。本研究旨在调查美国成年人中动物源性膳食铁（ADDI）摄入量、植物源性膳食铁（PDDI）摄入量以及 PDDI:ADDI 比值与 NAFLD 风险之间的关联。

方法和研究设计

这是一项重复的横断面研究。数据来自 2007-2018 年全国健康和营养调查（NHANES）。NAFLD 定义为美国肥胖生活指数（USFLI）≥30，膳食铁摄入量通过两次 24 小时膳食回忆访谈进行评估。应用逻辑回归和限制立方样条模型来检验不同来源的膳食铁摄入与 NAFLD 风险之间的关联。

结果

本研究共纳入 9478 名年龄≥20 岁的参与者。在调整了多种混杂因素后，与最低四分位相比，ADDI 摄入量最高四分位的 NAFLD 比值比（OR）和 95%置信区间（CI）为 1.01（95%CI，0.82-1.24），PDDI 摄入量为 0.82（95%CI，0.64-0.99），PDDI:ADDI 摄入量比为 1.00（95%CI，0.81-1.24）。按性别和年龄分层分析，PDDI 摄入量与 NAFLD 呈显著负相关，仅在女性和年龄大于 45 岁的参与者中观察到。剂量反应分析表明，PDDI 摄入量与 NAFLD 呈非线性负相关。