Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang, P.R. China.
Collaborative innovation center for antitumor active substance research and development, Guangdong Medical University, Zhanjiang, P.R. China.
Asia Pac J Clin Nutr. 2021;30(1):140-152. doi: 10.6133/apjcn.202103_30(1).0017.
Although fish consumption or omega-3 intake is associated with cardio- cerebrovascular disease including stroke, their correlation is still controversial. Therefore, this meta-analysis is to identify the relationship between the risk of stroke and fish consumption or omega-3 intake.
We searched the PubMed, EMBASE and Cochrane Library databases as of May 2019. Multivariateadjusted risk ratios (RRs) with 95% confidence interval (CI) for stroke in different level intake of fish or Longchain omega-3 polyunsaturated fatty acids (LC ω3-PUFAs) were pooled using a random-effects meta-analysis. A dose-response analysis was conducted with the 2-stage generalized least-squares trend program.
Our meta-analysis identified a total of 17 prospective cohort studies including 14986 strokes events in 672711 individuals. Meta-analysis revealed that the higher fish consumption was significantly associated with lower risk of stroke (RR=0.871, 95% CI: 0.779-0.975, p=0.016), especially with ischemic stroke (RR=0.808, 95% CI: 0.696- 0.937, p=0.005). Meantime, the combined RR of total stroke was 0.859 (95% CI: 0.769-0.959, p=0.007) for the highest versus lowest intake of LC ω3-PUFAs, and stratification analysis showed that higher LC ω3-PUFAs intake was associated with reduced stroke risk in women (RR=0.793, 95% CI: 0.706-0.891, p=0.000) but not in men. In addition, the dose-response analysis showed fish consumption with 1000g per month and LC ω3-PUFAs intake with 0.5g per month was associated with 17.3% (RR=0.927, 95% CI: 0.83-0.98) and 14% (RR=0.86, 95% CI: 0.78-0.95) lower risk of stroke, respectively.
Both fish consumption and LC ω3-PUFAs intake were negatively associated with the risk of stroke, especially in women, which suggest that increased intake of fishery products and LC ω3-PUFAs may benefit primary prevention of stroke.
尽管鱼类消费或ω-3 摄入与包括中风在内的心脑血管疾病有关，但它们之间的相关性仍存在争议。因此，本荟萃分析旨在确定鱼类消费或ω-3 摄入与中风风险之间的关系。
我们检索了截至 2019 年 5 月的 PubMed、EMBASE 和 Cochrane 图书馆数据库。使用随机效应荟萃分析，汇总了不同水平鱼类或长链ω-3 多不饱和脂肪酸（LC ω3-PUFA）摄入与中风风险的多变量校正风险比（RR）和 95%置信区间（CI）。使用 2 阶段广义最小二乘趋势程序进行剂量反应分析。
本荟萃分析共纳入了 17 项前瞻性队列研究，涉及 672711 名个体中的 14986 例中风事件。荟萃分析显示，较高的鱼类消费与较低的中风风险显著相关（RR=0.871，95%CI：0.779-0.975，p=0.016），尤其是与缺血性中风（RR=0.808，95%CI：0.696-0.937，p=0.005）。同时，最高与最低 LC ω3-PUFA 摄入量相比，总中风的合并 RR 为 0.859（95%CI：0.769-0.959，p=0.007），分层分析表明，LC ω3-PUFA 摄入量较高与女性中风风险降低相关（RR=0.793，95%CI：0.706-0.891，p=0.000），但与男性无关。此外，剂量反应分析表明，每月摄入 1000 克鱼类和每月摄入 0.5 克 LC ω3-PUFA 与 17.3%（RR=0.927，95%CI：0.83-0.98）和 14%（RR=0.86，95%CI：0.78-0.95）的中风风险降低相关。
鱼类消费和 LC ω3-PUFA 摄入均与中风风险呈负相关，尤其是在女性中，这表明增加渔业产品和 LC ω3-PUFA 的摄入可能有益于中风的一级预防。
