Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Department of NCDs Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
J Diabetes Investig. 2021 Oct;12(10):1784-1796. doi: 10.1111/jdi.13556. Epub 2021 Jun 5.
AIMS/INTRODUCTION: Metabolic syndrome (MS) has been increasing worldwide. The secular change in MS components, however, remains unclear. This study aimed to examine the dynamic change in metabolic health status in Chinese adults.
Three population-based surveys using multistage stratified sampling were performed in Chinese aged 35-74 years in Shanghai in 2002-2003 (n = 12,302), 2009 (n = 7,400), and 2017 (n = 19,023). MS was defined according to the Adult Treatment Panel III criteria for Asian-Americans. Generalized Estimating Equations and Cochran-Armitage Trend Test was used to assess the prevalence trend over the years.
The prevalence of MS doubled in Chinese adults over the period (P for trend < 0.001). The largest increase occurred in younger men. Among MS components, the prevalence of high waist-circumference (HWC), high blood glucose (HBG) and high blood pressure (HBP) increased in all subjects, whereas the prevalence of high triglycerides (HTG) and low high-density lipoprotein cholesterol (LHC) increased in men but decreased in women. The increase in HBP contributed most to elevated MS, followed by HBG and HWC, resulting in the HBP-HBG-HWC the most common cluster of MS components. Metabolically unhealthy overweight also grew over the period.
Metabolic health status has been exacerbating in Chinese adults and may increase burden of non-communicable diseases.
目的/引言：代谢综合征（MS）在全球范围内呈上升趋势。然而，MS 成分的长期变化仍不清楚。本研究旨在探讨中国成年人代谢健康状况的动态变化。
在上海，采用多阶段分层抽样方法，对 2002-2003 年（n=12302）、2009 年（n=7400）和 2017 年（n=19023）年龄在 35-74 岁的三个人群进行了三次基于人群的调查。MS 根据亚洲美国人的成人治疗小组 III 标准定义。采用广义估计方程和 Cochran-Armitage 趋势检验评估多年来的患病率趋势。
在这段时间内，中国成年人 MS 的患病率增加了一倍（趋势 P<0.001）。这种增长在年轻男性中最为明显。在 MS 成分中，高腰围（HWC）、高血糖（HBG）和高血压（HBP）的患病率在所有人群中均增加，而高甘油三酯（HTG）和低高密度脂蛋白胆固醇（LHC）的患病率在男性中增加，而在女性中减少。HBP 的增加对 MS 的升高贡献最大，其次是 HBG 和 HWC，导致 HBP-HBG-HWC 成为最常见的 MS 成分集群。代谢不健康的超重也在这段时间内增加。
中国成年人的代谢健康状况一直在恶化，这可能会增加非传染性疾病的负担。
