Department of Epidemiology, School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education (Fudan University), 138 Yi Xue Yuan Road, Shanghai 200032, China.
BMC Public Health. 2010 May 12;10:246. doi: 10.1186/1471-2458-10-246.
The prevalence of metabolic syndrome (MS) has been increasing in China in recent years. The aim of this study is to estimate and compare the prevalence of MS among Chinese adults in Shanghai, one of the most economic developed areas in China, using definitions proposed by World Health Organization (WHO), National Cholesterol Education Program Adult Treatment Panel (modified ATP III) and International Diabetes Federation (IDF).
This cross-sectional study included 5,584 adults at age 20-79 randomly selected from Pudong New Area of Shanghai, China, through a three-stage sampling. All participants were interviewed in-person between April and July of 2008 to collect information on demographic and lifestyle characteristics. At the interview, anthropometry and blood pressure were measured and bio-specimens were collected.
The prevalence estimates for the MS increased with age for each definition in men and women, but the estimates varied greatly between the definitions and by sex. The prevalence of the MS was higher in men (20.2%) than in women (18.7%) using WHO definition but this sex difference was reversed when using the modified ATP III (28.4% for men vs. 35.1% for women) and the IDF (15.9% for men vs. 26.7% for women) criteria. The most common metabolic disorder in this population was dyslipidaemia, regardless of the definition used. Substantial agreement, estimated using the kappa statistic, was found between the modified ATP III and IDF definition, whereas the lowest agreement was observed between the WHO and ATP III criteria.
The MS is highly prevalent among Chinese adults in Pudong New Area of Shanghai and the most prevalent component was dyslipidemia. These findings underscore the importance of prevention and control efforts for the MS in this area and the need for a unified predictive definition for the syndrome for use by clinical practitioners and public health agencies.
近年来，中国代谢综合征（MS）的患病率呈上升趋势。本研究旨在采用世界卫生组织（WHO）、美国国家胆固醇教育计划成人治疗专家组（改良 ATPIII）和国际糖尿病联盟（IDF）的定义，评估和比较中国上海经济发达地区成年人的 MS 患病率。
本横断面研究纳入了来自中国上海浦东新区的 5584 名 20-79 岁的成年人，采用三阶段抽样方法随机选择。所有参与者于 2008 年 4 月至 7 月间进行了面对面访谈，以收集人口统计学和生活方式特征信息。访谈时，测量了人体测量学和血压，并采集了生物标本。
在男性和女性中，每种定义的 MS 患病率均随年龄增长而增加，但各定义之间以及性别之间的估计值差异很大。采用 WHO 定义时，MS 在男性（20.2%）中的患病率高于女性（18.7%），但采用改良 ATPIII 定义时，男女之间的这种性别差异则相反（男性为 28.4%，女性为 35.1%），而采用 IDF 定义时，男性（15.9%）的患病率低于女性（26.7%）。无论采用哪种定义，该人群最常见的代谢紊乱都是血脂异常。使用 Kappa 统计量估计，改良 ATPIII 和 IDF 定义之间具有显著一致性，而 WHO 和 ATPIII 标准之间的一致性最低。
上海浦东新区的中国成年人中 MS 的患病率很高，最常见的组成部分是血脂异常。这些发现强调了该地区对 MS 进行预防和控制的重要性，以及临床医生和公共卫生机构对该综合征采用统一预测定义的必要性。
