Chen Lei, Tiwari Shashi Ranjan, Zhang Yingqi, Zhang Jincheng, Sun Yeqing
Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, P. R. China.
ACS Biomater Sci Eng. 2021 Apr 12;7(4):1686-1692. doi: 10.1021/acsbiomaterials.1c00005. Epub 2021 Mar 31.
Osteoarthritis (OA) is a progressive degenerative joint disease whose molecular mechanism has not been revealed clearly, and there is still no effective approach to cure OA completely. Recently, reactive oxygen species (ROS) are exposed as an important mediator of OA's inflammatory response, and it has been regarded as a therapeutic target for OA treatment. MnO nanoparticles possess good biocompatibility and can act as an artificial nanoenzyme to scavenge ROS in various diseases effectively. In this study, the modified Stöber method was applied to synthesize hollow MnO (H-MnO) and H-MnO was modified with NH-PEG-NH, which possesses excellent biological stability and biocompatibility. It induced a change in the articular cartilage structure changes , with the knee tissue staining and micro-CT scanning of the whole knee suggesting that H-MnO nanoparticles could effectively remove ROS and significantly relieve the inflammatory response of OA without obvious side effects. This study reveals the therapeutic effects of MnO-based nanomedicine toward OA, which provides potential alternative therapeutic options for patients with inflammation tissue.
骨关节炎（OA）是一种进行性退行性关节疾病，其分子机制尚未完全阐明，目前仍没有完全治愈OA的有效方法。近年来，活性氧（ROS）被发现是OA炎症反应的重要介质，并被视为OA治疗的一个靶点。MnO纳米颗粒具有良好的生物相容性，可作为人工纳米酶有效清除多种疾病中的ROS。本研究采用改进的Stöber法合成中空MnO（H-MnO），并用具有优异生物稳定性和生物相容性的NH-PEG-NH对其进行修饰。它引起了关节软骨结构的变化，膝关节组织染色和全膝关节微CT扫描表明，H-MnO纳米颗粒能有效清除ROS，显著减轻OA的炎症反应，且无明显副作用。本研究揭示了基于MnO的纳米药物对OA的治疗作用，为炎症组织患者提供了潜在的替代治疗选择。
