Universidade Federal de Minas Gerais, Departamento de Parasitologia, Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais, Departamento de Bioquímica e Imunologia, Belo Horizonte, MG, Brasil.
Mem Inst Oswaldo Cruz. 2021 Mar 29;116:e200634. doi: 10.1590/0074-02760200634. eCollection 2021.
The availability of Trypanosomatid genomic data in public databases has opened myriad experimental possibilities that have contributed to a more comprehensive understanding of the biology of these parasites and their interactions with hosts. In this review, after brief remarks on the history of the Trypanosoma cruzi and Leishmania genome initiatives, we present an overview of the relevant contributions of genomics, transcriptomics and functional genomics, discussing the primary obstacles, challenges, relevant achievements and future perspectives of these technologies.
寄生虫基因组数据在公共数据库中的可用性为实验提供了无数的可能性，有助于更全面地了解这些寄生虫的生物学及其与宿主的相互作用。在简要回顾了克氏锥虫和利什曼原虫基因组计划的历史之后，我们介绍了基因组学、转录组学和功能基因组学的相关贡献，讨论了这些技术的主要障碍、挑战、相关成就和未来展望。
