Clement P B, Young R H, Scully R E
Department of Pathology, Vancouver General Hospital, Canada.
Hum Pathol. 1988 Jun;19(6):657-62. doi: 10.1016/s0046-8177(88)80171-0.
Granulosa cell proliferations that simulated small neoplasms were incidental findings in the ovaries of nine pregnant women. The lesions were typically multiple and associated with atretic follicles. In eight cases, the granulosa cells were arranged in solid, insular, microfollicular, and trabecular patterns, but in the ninth case, there was a prominent sertoliform tubular pattern. The granulosa cells typically contained scanty cytoplasm and grooved nuclei, resembling the cells of adult-type granulosa cell tumors. However, in one case large nodules of markedly luteinized cells with variably sized, round, nongrooved nuclei were present; the nodules in this case superficially resembled pregnancy luteomas. In the case with a sertoliform pattern, the cells had abundant vacuolated cytoplasm. The lesions described probably reflect an unusual physiological response to the elevated chorionic gonadotropin level of pregnancy rather than early stages of neoplasia.
在9名孕妇的卵巢中，偶然发现了类似小肿瘤的颗粒细胞增生。这些病变通常为多发，并与闭锁卵泡相关。8例中，颗粒细胞呈实性、岛状、微滤泡状和小梁状排列，但在第9例中，有显著的支持细胞样管状结构。颗粒细胞通常含有少量细胞质和有沟核，类似于成年型颗粒细胞肿瘤的细胞。然而，在1例中，存在明显黄体化细胞的大结节，其核大小不一、圆形、无沟；该例中的结节表面上类似于妊娠黄体瘤。在具有支持细胞样结构的病例中，细胞具有丰富的空泡状细胞质。所描述的病变可能反映了对妊娠时绒毛膜促性腺激素水平升高的一种不寻常的生理反应，而非肿瘤形成的早期阶段。
