University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Makerere University, Kampala, Uganda.
J Neurovirol. 2021 Jun;27(3):487-492. doi: 10.1007/s13365-021-00969-x. Epub 2021 Mar 31.
We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p < .001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.
我们调查了在乌干达农村地区的 HIV 感染者（PWH）中衰弱的患病率和风险因素（n=55，47%为男性，平均年龄 44 岁）。根据 Fried 标准定义衰弱，用自我报告的体力活动水平替代明尼苏达州休闲时间活动问卷。替代体力活动的分类方法是撒哈拉以南非洲活动问卷和国际体力活动问卷。11 名参与者（19%）衰弱。虚弱的参与者年龄更大（p<0.001），不太可能接受抗逆转录病毒治疗（p=0.03），抑郁（p<.001）和 HIV 相关神经认知障碍（p=0.003）的发生率更高。体力活动测量之间的一致性不太理想。在乌干达农村地区，PWH 中衰弱的患病率很高，但需要更大的样本量和本地规范数据。
