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Zinc(II)-The Overlooked Éminence Grise of Chloroquine's Fight against COVID-19?锌(II)——氯喹抗击新冠病毒中被忽视的幕后关键因素?
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Structure of the RNA-dependent RNA polymerase from COVID-19 virus.COVID-19 病毒的依赖 RNA 的 RNA 聚合酶的结构。
Science. 2020 May 15;368(6492):779-782. doi: 10.1126/science.abb7498. Epub 2020 Apr 10.
6
Membrane Permeabilities of Ascorbic Acid and Ascorbate.抗坏血酸和抗坏血酸盐的膜通透性。
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Zinc-chelated Vitamin C Stimulates Adipogenesis of 3T3-L1 Cells.锌螯合维生素C刺激3T3-L1细胞的脂肪生成。
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8
Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli.抗坏血酸锌具有超氧化物歧化酶样活性,并具有体外抗金黄色葡萄球菌和大肠杆菌的抗菌活性。
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9
Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.锌(2+)在体外抑制冠状病毒和动脉病毒 RNA 聚合酶的活性,而锌离子载体则阻断这些病毒在细胞培养中的复制。
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10
A glass of water immediately increases gastric pH in healthy subjects.一杯水会立即提高健康受试者的胃内pH值。
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假设抗坏血酸锌作为提高针对 COVID-19 的抗病毒抗性的最佳锌离子载体。

Hypothesis of zinc ascorbate as best zinc ionophore for raising antiviral resistance against Covid-19.

机构信息

Recanati, Italy.

出版信息

J Med Virol. 2021 Sep;93(9):5205-5208. doi: 10.1002/jmv.26989. Epub 2021 May 28.

DOI:10.1002/jmv.26989
PMID:33788302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8250578/
Abstract

Zinc ascorbate could prevent and treat Covid‐19 by raising antiviral resistance to SARS‐CoV‐2 virus via increase of intracellular zinc concentration as a zinc ionophore more than other salts of zinc or zinc with vitamin C. Tests in vitro and clinical trials for Covid‐19 prevention and treatment with zinc ascorbate are strongly recommended and should start as soon as possible. Potential advantages of zinc ascorbate supplementation over vaccines and drugs are also discussed, with supplementation suggestions.

摘要

抗坏血酸锌通过增加细胞内锌浓度作为锌载体,比其他锌盐或锌与维生素 C 更能提高抗病毒对 SARS-CoV-2 病毒的抵抗力,从而可以预防和治疗 Covid-19。强烈建议对锌抗坏血酸进行体外测试和临床试验,以预防和治疗 Covid-19,并且应尽快开始。还讨论了锌抗坏血酸补充剂相对于疫苗和药物的潜在优势,并提出了补充建议。