De Rose V, Ferrara A, Mangiarotti P, Nonis A, Bertoletti R, Gialdroni Grassi G
Institute of Respiratory Diseases, University of Pavia, Italy.
Int J Clin Pharmacol Res. 1988;8(2):107-10.
Roxithromycin sputum and serum concentrations after administration of therapeutic doses (150 mg in a single dose) were evaluated in six patients. Blood samples and pooled sputum samples were collected at corresponding time intervals up to 24 h after drug administration. Roxithromycin sputum levels were found to be almost always above serum concentrations, the highest sputum levels being 5.85 +/- 2.5 micrograms/ml in the interval ranging from 2 to 4 h after drug administration. Due to its antibacterial spectrum and favourable pharmacokinetic properties, roxithromycin, like other macrolide antibiotics, seems to be particularly indicated in the treatment of respiratory tract infections.
对6名患者给予治疗剂量（单次150毫克）后，评估了罗红霉素在痰液和血清中的浓度。在给药后长达24小时的相应时间间隔采集血样和混合痰液样本。发现罗红霉素的痰液水平几乎总是高于血清浓度，给药后2至4小时期间最高痰液水平为5.85±2.5微克/毫升。由于其抗菌谱和良好的药代动力学特性，罗红霉素与其他大环内酯类抗生素一样，似乎特别适用于治疗呼吸道感染。
