Mounier M, Renaudie P, Baudet J, Denis F
Service de Bactériologie-Virologie, Centre Hospitalier Universitaire Dupuytren, Limoges.
Pathol Biol (Paris). 1989 May;37(5):424-7.
We studied the diffusion of roxithromycin in the cervix mucus of fifteen healthy normal women, aged 24 to 44 (median 37). They were consulting physician to have an IUD. After this intervention (between the 4 to 7 days of menstrual cycle) they received an antibiotic treatment with the standard dose of roxithromycin: 150 mg bd for a week. At the end of this treatment the cervix mucus was taken 1 to 12 hours after the last antibiotic dose. We dose the roxithromycin by a microbial assay (Bacillus subtilis ATCC 6633, antibiotic medium 1, pH 8) and the acid alpha-1-glycoprotein by an immunodiffusion assay. All women had drug measurable with levels from 0.45 to 2.07 mg/l (median: 0.80 mg/l). The acid alpha-1-glycoprotein levels were quite constant (median: 0.19 mg/l). The antibiotic concentrations observed are above the MIC of the major genital pathogens, mainly C. trachomatis, G. vaginalis, H. ducreyi and U. urealyticum, but lower than the MIC ov N. gonorrhoeae and M. hominis.
我们研究了罗红霉素在15名年龄在24至44岁（中位数为37岁）的健康正常女性宫颈黏液中的扩散情况。她们因要放置宫内节育器而咨询医生。在该干预措施后（月经周期的第4至7天之间），她们接受了标准剂量罗红霉素的抗生素治疗：150毫克，每日两次，持续一周。在该治疗结束时，于最后一剂抗生素给药后1至12小时采集宫颈黏液。我们通过微生物测定法（枯草芽孢杆菌ATCC 6633，抗生素培养基1，pH 8）测定罗红霉素，通过免疫扩散测定法测定酸性α-1-糖蛋白。所有女性体内均可检测到药物，水平为0.45至2.07毫克/升（中位数：0.80毫克/升）。酸性α-1-糖蛋白水平相当稳定（中位数：0.19毫克/升）。观察到的抗生素浓度高于主要生殖病原体的最低抑菌浓度，主要是沙眼衣原体、阴道加德纳菌、杜克嗜血杆菌和解脲脲原体，但低于淋病奈瑟菌和人型支原体的最低抑菌浓度。
