Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Anticancer Res. 2021 Mar;41(3):1593-1598. doi: 10.21873/anticanres.14920.
BACKGROUND/AIM: We previously showed that an elevated postoperative serum C-reactive protein (CRP) level has a negative impact on long-term survival outcomes, regardless of the occurrence of infectious complications in colorectal cancer. However, the cause of postoperative inflammation could not be properly evaluated, because patient background factors, such as the surgical approach (open/laparoscopic), were not unified.
A total of 277 patients who underwent laparoscopic surgery for stage II/III colorectal cancer were enrolled.
The high-CRP group had lower relapse-free and overall survival rates in comparison to the low-CRP group. A high postoperative serum CRP level was significantly associated with a larger tumor diameter and longer operation time, and tended to be associated with a higher T stage and larger amount of bleeding.
Larger tumor volume, longer operation time and larger amount of bleeding were associated with the promotion of postoperative inflammation, which worsened long-term survival outcomes in colorectal cancer.
背景/目的：我们之前的研究表明，结直肠癌患者术后血清 C 反应蛋白（CRP）水平升高对长期生存结果有负面影响，而不论是否发生感染性并发症。然而，由于手术方式（开腹/腹腔镜）等患者背景因素未统一，无法对术后炎症的原因进行适当评估。
共纳入 277 例接受腹腔镜手术治疗的 II/III 期结直肠癌患者。
与 CRP 低水平组相比，CRP 高水平组的无复发生存率和总生存率较低。术后高血清 CRP 水平与肿瘤直径较大、手术时间较长显著相关，且与 T 分期较高、出血量较大有一定相关性。
较大的肿瘤体积、较长的手术时间和较大的出血量与术后炎症的发生有关，这会使结直肠癌的长期生存结果恶化。
