Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
Department of Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Anticancer Res. 2021 May;41(5):2605-2610. doi: 10.21873/anticanres.15040.
BACKGROUND/AIM: Recently, elevated levels of postoperative inflammatory markers have been reported to be associated with poorer long-term survival outcomes, regardless of the occurrence of infectious complications, in gastroenterological malignancies. The aim of this study was to evaluate the association between postoperative inflammation and shorter long-term survival after resection of colorectal liver metastases.
A total of 104 patients who underwent R0 resection for colorectal liver metastases were enrolled. The CRP levels were defined as the highest postoperative serum C-reactive protein levels during hospital stay.
The high-CRP group had a significantly lower relapse-free survival rate than the low-CRP group, regardless of the occurrence of infectious complications.
In colorectal liver metastasis as well as other malignancies, elevated postoperative levels of serum C-reactive protein are associated with shorter long-term survival, regardless of the occurrence of infectious complications.
背景/目的：最近，有报道称，在胃肠道恶性肿瘤中，无论是否发生感染性并发症，术后炎症标志物水平升高与较差的长期生存结局相关。本研究旨在评估结直肠肝转移切除术后术后炎症与短期长期生存之间的关系。
共纳入 104 例接受 R0 切除治疗的结直肠肝转移患者。CRP 水平定义为住院期间术后血清 C-反应蛋白水平的最高值。
高 CRP 组的无复发生存率明显低于低 CRP 组，无论是否发生感染性并发症。
在结直肠肝转移以及其他恶性肿瘤中，术后血清 C-反应蛋白水平升高与较短的长期生存相关，无论是否发生感染性并发症。
