白蛋白-胆红素（ALBI）分级对非小细胞肺癌预后的影响：倾向评分匹配分析。
Prognostic Impact of Albumin-bilirubin (ALBI) Grade on Non-small Lung Cell Carcinoma: A Propensity-score Matched Analysis.
机构信息
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Medical Information Center, Kyushu University Hospital, Fukuoka, Japan.
出版信息
Anticancer Res. 2021 Mar;41(3):1621-1628. doi: 10.21873/anticanres.14924.
BACKGROUND/AIM: Albumin-bilirubin (ALBI) grade is an indicator of liver dysfunction and is useful for predicting postoperative prognosis of hepatocellular carcinomas. However, the significance of ALBI grade in non-small cell lung carcinoma (NSCLC) has not been elucidated.
PATIENTS AND METHODS
We analyzed 947 patients with pStage IA-IIIA NSCLC. We divided patients into ALBI grade 1 and grade 2/3 groups. We then analyzed the association of ABLI grade with clinicopathological characteristics and prognosis in NSCLC by using propensity-score matching.
RESULTS
ALBI grade 2/3 was significantly associated with older age, male sex, advanced pT status, and histological type. Even after propensity-score matching, ALBI grade 2/3 patients had significantly worse cancer-specific survival (CSS) than ALBI grade 1 patients (5-year CSS: 87.3% versus 92.8%; p=0.0247). In multivariate analysis, ALBI grade 2/3 was an independent predictor of CSS (HR=1.9; 95%CI=1.11-3.11; p=0.0177).
CONCLUSION
ALBI grade was an independent prognostic factor in surgically resected NSCLC.
背景/目的：白蛋白-胆红素（ALBI）分级是肝功能的指标，可用于预测肝细胞癌的术后预后。然而，ALBI 分级在非小细胞肺癌（NSCLC）中的意义尚未阐明。
患者与方法
我们分析了 947 例 pStage IA-IIIA NSCLC 患者。我们将患者分为 ALBI 分级 1 组和 2/3 组。然后，我们通过倾向评分匹配分析了 ALBI 分级与 NSCLC 的临床病理特征和预后的关系。
结果
ALBI 分级 2/3 与年龄较大、男性、较晚的 pT 分期和组织学类型显著相关。即使在进行倾向评分匹配后，ALBI 分级 2/3 组的患者癌症特异性生存率（CSS）明显低于 ALBI 分级 1 组（5 年 CSS：87.3% vs. 92.8%；p=0.0247）。多因素分析显示，ALBI 分级 2/3 是 CSS 的独立预后因素（HR=1.9；95%CI=1.11-3.11；p=0.0177）。
结论
ALBI 分级是手术切除的 NSCLC 的独立预后因素。
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