Shi Xiuying, Zhang Shuyi, Bao Baijun, Cong Hui, Lu Xiaomin, Shi Aijun
Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Biomark Med. 2025 Feb;19(3):73-79. doi: 10.1080/17520363.2025.2455928. Epub 2025 Jan 21.
The objective of this study was to investigate the prognostic significance of the preoperative serum albumin-bilirubin (ALBI) score in patients with colorectal cancer (CRC).
Preoperative ALBI data from 1506 CRC patients were categorized into high-value and low-value groups, and the clinicopathological characteristics of these groups were compared. A Cox proportional hazards regression model was employed to investigate the risk factors associated with distant metastasis. The Kaplan-Meier method and log-rank test were utilized to analyze the relationship between ALBI scores and 5-year distant metastasis-free survival (DMFS).
The incidence of distant metastasis in group B (ALBI ≥ -2.4) was significantly higher at 28.81% compared to group A (ALBI < -2.4), which had an incidence of 23.36% ( = 0.018). ALBI score ≥ -2.4 was identified as an independent risk factor for postoperative distant metastasis of CRC (HR = 1.251, 95%CI: 1.021-1.533, = 0.031). The incidence of 5-year DMFS was significantly lower in the ALBI ≥ -2.4 group compared to that observed in the ALBI < -2.4 group (χ = 5.97, = 0.015, log-rank test).
The ALBI score of ≥ -2.4 emerges as an independent risk factor for the occurrence of distant metastases following CRC surgery.
本研究旨在探讨术前血清白蛋白-胆红素（ALBI）评分在结直肠癌（CRC）患者中的预后意义。
将1506例CRC患者的术前ALBI数据分为高值组和低值组，并比较两组的临床病理特征。采用Cox比例风险回归模型研究与远处转移相关的危险因素。运用Kaplan-Meier法和对数秩检验分析ALBI评分与5年无远处转移生存率（DMFS）之间的关系。
B组（ALBI≥-2.4）远处转移发生率为28.81%，显著高于A组（ALBI＜-2.4）的23.36%（P = 0.018）。ALBI评分≥-2.4被确定为CRC术后远处转移的独立危险因素（HR = 1.251，95%CI：1.021-1.533，P = 0.031）。ALBI≥-2.4组的5年DMFS发生率显著低于ALBI＜-2.4组（χ= 5.97，P = 0.015，对数秩检验）。
ALBI评分≥-2.4是CRC手术后发生远处转移的独立危险因素。
