在治疗尿路感染中，影响对萘啶酸产生耐药性的因素。
Factors governing the emergence of resistance to nalidixic acid in treatment of urinary tract infection.
作者信息
Greenwood D, O'Grady F
出版信息
Antimicrob Agents Chemother. 1977 Dec;12(6):678-81. doi: 10.1128/AAC.12.6.678.
Abstract
Cultures of Escherichia coli were exposed to nalidixic acid in an in vitro model in which the conditions of drug-organism interaction resembled those of bacterial cystitis treatment. Results obtained in this way suggested that emergence of bacterial resistance should not be a major problem in treatment of uncomplicated urinary infection; such cases might indeed respond to a less intensive course of treatment than is usual. More prolonged, high-dosage therapy with nalidixic acid may be required for patients with more complicated infections if the risk of failure from the emergence of bacterial resistance is to be minimized.
摘要
在一个体外模型中，将大肠杆菌培养物暴露于萘啶酸中，该模型中药物与生物体的相互作用条件类似于细菌性膀胱炎的治疗情况。通过这种方式获得的结果表明，在单纯性泌尿系统感染的治疗中，细菌耐药性的出现不应成为一个主要问题；此类病例可能确实对强度低于常规的治疗疗程有反应。如果要将因细菌耐药性出现而导致治疗失败的风险降至最低，对于感染情况更复杂的患者，可能需要更长时间、更高剂量的萘啶酸治疗。
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本文引用的文献
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NALIDIXIC ACID IN URINARY INFECTIONS.萘啶酸在尿路感染中的应用
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